التفاصيل البيبلوغرافية
| العنوان: |
Growth Hormone Response to Hyperinsulinaemia in Insulin‐dependent Diabetics Comparison of Patients With and Without Retinopathy |
| المؤلفون: |
Sharp, P. S., Foley, K., Vitelli, F., Maneschi, F., Kohner, E. M. |
| المصدر: |
Diabetic Medicine ; volume 1, issue 1, page 55-58 ; ISSN 0742-3071 1464-5491 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
1984 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Growth hormone levels were measured in glucose clamp studies on 13 insulin‐dependent diabetic patients with retinopathy and 9 age, sex, and weight matched patients without retinopathy. Four non‐diabetic subjects were used as controls. The glucose was kept constant at 12 ± 0.85 mmol/I (mean±S.D.) in the diabetic groups, and at 6 mmol/I in the non‐diabetic controls. Insulin was infused at sequential rates of 0.3, 1.0, and 10 mU/kg/min. Basal levels of growth hormone were not significantly different in those with and without retinopathy (5.7 ± 4.9, 9.4± 10.6 mU/I p = 0.21). Growth hormone levels were compared in each group during a 60 minute steady state period for each insulin infusion rate. At all 3 infusion rates, the diabetics with retinopathy produced a rise in growth hormone, while the non‐diabetics did not (1.24 ± 0.6 mU/I). The patients with retinopathy produced more growth hormone than those without at each infusion rate (12.2 ± 11.5 vs. 2.8 ± 5.1, p = 0.03; 10.6±11.1 vs. 1.6±1.7, p = 0.02; 19.7±20.6 vs. 4.2 ± 4.8, p = 0.03). These data confirm that insulin alone can stimulate growth hormone secretion in insulin‐dependent diabetics with retinopathy. Evidence is provided indicating that patients with retinopathy produce more growth hormone than those without. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/j.1464-5491.1984.tb01924.x |
| الإتاحة: |
https://doi.org/10.1111/j.1464-5491.1984.tb01924.xTest |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.5342FDAA |
| قاعدة البيانات: |
BASE |
