التفاصيل البيبلوغرافية
| العنوان: |
Normal human follicle development: an evaluation of correlations with oestradiol, androstenedione and progesterone levels in individual follicles |
| المؤلفون: |
Thierry van Dessel, H. J. H. M., Schipper, Izaak, Pache, Thierry D., Van Geldorp, Hans, De Jong, Frank H, Fauser, Bart C. J. M. |
| المصدر: |
Clinical Endocrinology ; volume 44, issue 2, page 191-198 ; ISSN 0300-0664 1365-2265 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
1996 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
OBJECTIVE The mechanism of dominant follicle selection remains obscure.We have investigated the association between follicle diameter and follicular steroid levels in individual human ovarian follicles throughout the menstrual cycle. DESIGN Fluid from ovarian follicles ( n = 326) was obtained in vivo during surgery from 55 regularly cycling women with proven fertility. Follicles were divided into dominant (diameter > 9 mm, n = 45) and non‐dominant (diameter ≤ 9 mm, n = 281) based on ultrasound measurements. MEASUREMENTS Fluid was assayed for oestradiol (E 2 ), androstenedione (AD), and progesterone (P). RESULTS Median P and E 2 levels were significantly lower ( P < 0.0001) and AD levels significantly higher ( P = 0.03) in non‐dominant as compared to dominant follicles. In non‐dominant follicles AD ( r = 0.14, P = 0.02), but not P and E 2 , levels were correlated to follicular diameter, and significant changes in steroid concentrations across the menstrual cycle were absent. In dominant follicles, diameter was positively correlated with P and E 2 ( P < 0.001) levels, and inversely correlated with AD concentrations ( P = 0.01). CONCLUSIONS Results indicate that (1) intrafollicular oestradiol concentrations rise only in follicles exceeding 9 mm in diameter and correlate with the diameter of these dominant follicles, suggesting that significant increase in aromatase enzyme activity occurs only in the dominant follicle (2) a cycle‐independent accumulation of andro‐stenedione with size occurs in non‐dominant follicles, and (3) progesterone production occurs in the largest dominant follicles only, suggesting a limited, if any, role for progesterone during follicle development. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1046/j.1365-2265.1996.662483.x |
| الإتاحة: |
https://doi.org/10.1046/j.1365-2265.1996.662483.xTest |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.7DACECAE |
| قاعدة البيانات: |
BASE |
