التفاصيل البيبلوغرافية
| العنوان: |
IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation |
| المؤلفون: |
Yánez, Diana C., Sahni, Hemant, Ross, Susan, Solanki, Anisha, Lau, Ching‐In, Papaioannou, Eleftheria, Barbarulo, Alessandro, Powell, Rebecca, Lange, Ulrike C., Adams, David J., Barenco, Martino, Ono, Masahiro, D'Acquisto, Fulvio, Furmanski, Anna L., Crompton, Tessa |
| المساهمون: |
Secretaría de Educación Superior, Ciencia, Tecnología e Innovación, Biotechnology and Biological Sciences Research Council, Medical Research Council |
| المصدر: |
European Journal of Immunology ; volume 49, issue 1, page 66-78 ; ISSN 0014-2980 1521-4141 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2018 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
The interferon‐inducible transmembrane ( Ifitm / Fragilis ) genes encode homologous proteins that are induced by IFNs. Here, we show that IFITM proteins regulate murine CD4 + Th cell differentiation. Ifitm2 and Ifitm3 are expressed in wild‐type (WT) CD4 + T cells. On activation, Ifitm3 was downregulated and Ifitm2 was upregulated. Resting Ifitm ‐family‐deficient CD4 + T cells had higher expression of Th1‐associated genes than WT and purified naive Ifitm ‐family‐deficient CD4 + T cells differentiated more efficiently to Th1, whereas Th2 differentiation was inhibited. Ifitm ‐family‐deficient mice, but not Ifitm3 ‐deficient mice, were less susceptible than WT to induction of allergic airways disease, with a weaker Th2 response and less severe disease and lower Il4 but higher Ifng expression and IL‐27 secretion. Thus, the Ifitm family is important in adaptive immunity, influencing Th1/Th2 polarization, and Th2 immunopathology. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/eji.201847692 |
| الإتاحة: |
https://doi.org/10.1002/eji.201847692Test |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.568BC3B5 |
| قاعدة البيانات: |
BASE |
