التفاصيل البيبلوغرافية
| العنوان: |
Atypical cerebellar functional connectivity at 9 months of age predicts delayed socio‐communicative profiles in infants at high and low risk for autism |
| المؤلفون: |
Okada, Nana J., Liu, Janelle, Tsang, Tawny, Nosco, Erin, McDonald, Nicole M., Cummings, Kaitlin K., Jung, Jiwon, Patterson, Genevieve, Bookheimer, Susan Y., Green, Shulamite A., Jeste, Shafali S., Dapretto, Mirella |
| المساهمون: |
Eunice Kennedy Shriver National Institute of Child Health and Human Development |
| المصدر: |
Journal of Child Psychology and Psychiatry ; volume 63, issue 9, page 1002-1016 ; ISSN 0021-9630 1469-7610 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2021 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Background While the cerebellum is traditionally known for its role in sensorimotor control, emerging research shows that particular subregions, such as right Crus I (RCrusI), support language and social processing. Indeed, cerebellar atypicalities are commonly reported in autism spectrum disorder (ASD), a neurodevelopmental disorder characterized by socio‐communicative impairments. However, the cerebellum’s contribution to early socio‐communicative development remains virtually unknown. Methods Here, we characterized functional connectivity within cerebro‐cerebellar networks implicated in language/social functions in 9‐month‐old infants who exhibit distinct 3‐year socio‐communicative developmental profiles. We employed a data‐driven clustering approach to stratify our sample of infants at high ( n = 82) and low ( n = 37) familial risk for ASD into three cohorts—Delayed, Late‐Blooming, and Typical—who showed unique socio‐communicative trajectories. We then compared the cohorts on indices of language and social development. Seed‐based functional connectivity analyses with RCrusI were conducted on infants with fMRI data ( n = 66). Cohorts were compared on connectivity estimates from a‐priori regions, selected on the basis of reported coactivation with RCrusI during language/social tasks. Results The three trajectory‐based cohorts broadly differed in social communication development, as evidenced by robust differences on numerous indices of language and social skills. Importantly, at 9 months, the cohorts showed striking differences in cerebro‐cerebellar circuits implicated in language/social functions. For all regions examined, the Delayed cohort exhibited significantly weaker RCrusI connectivity compared to both the Late‐Blooming and Typical cohorts, with no significant differences between the latter cohorts. Conclusions We show that hypoconnectivity within distinct cerebro‐cerebellar networks in infancy predicts altered socio‐communicative development before delays overtly manifest, which may be relevant for ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/jcpp.13555 |
| الإتاحة: |
https://doi.org/10.1111/jcpp.13555Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.EFCDE3E |
| قاعدة البيانات: |
BASE |
