التفاصيل البيبلوغرافية
| العنوان: |
Iloprost inhalation redistributes pulmonary perfusion and decreases arterial oxygenation in healthy volunteers |
| المؤلفون: |
RIMEIKA, D., SANCHEZ‐CRESPO, A., NYREN, S., LINDAHL, S. G. E., WIKLUND, C. U. |
| المصدر: |
Acta Anaesthesiologica Scandinavica ; volume 53, issue 9, page 1158-1166 ; ISSN 0001-5172 1399-6576 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2009 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Background: Previous studies have shown that ventilation–perfusion matching is improved in the prone as compared with that in the supine position. Regional differences in the regulation of vascular tone may explain this. We have recently demonstrated higher production of nitric oxide in dorsal compared with ventral human lung tissue. The purpose of the present study was to investigate regional differences in actions by another vasoactive mediator, namely prostacyclin. The effects on gas exchange and regional pulmonary perfusion in different body positions were investigated at increased prostacyclin levels by inhalation of a synthetic prostacyclin analogue and decreased prostacyclin levels by unselective cyclooxygenase (COX) inhibition. Methods: In 19 volunteers, regional pulmonary perfusion in the prone and supine position was assessed by single photon emission computed tomography using 99m Tc macro‐aggregated albumin before and after inhalation of iloprost, a stable prostacyclin analogue, or an intravenous infusion of a non‐selective COX inhibitor, diclofenac. In addition, gas distribution was assessed in seven subjects using 99m Tc‐labelled ultra‐fine carbon particles before and after iloprost inhalation in the supine position. Results: Iloprost inhalation decreased arterial PaO 2 in both prone (from 14.2±0.5 to 11.7±1.7 kPa, P <0.01) and supine (from 13.7±1.4 to 10.9±2.1 kPa, P <0.01) positions. Iloprost inhalation redistributed lung perfusion from non‐dependent to dependent lung regions in both prone and supine positions, while ventilation in the supine position was distributed in the opposite direction. No significant effects of non‐selective COX inhibition were found in this study. Conclusions: Iloprost inhalation decreases arterial oxygenation and results in a more gravity‐dependent pulmonary perfusion in both supine and prone positions in healthy humans. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/j.1399-6576.2009.02018.x |
| الإتاحة: |
https://doi.org/10.1111/j.1399-6576.2009.02018.xTest |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.42DA9CEC |
| قاعدة البيانات: |
BASE |
