التفاصيل البيبلوغرافية
| العنوان: |
Combination of fMRI and PET reveals the beneficial effect of three‐phase enriched environment on post‐stroke memory deficits by enhancing plasticity of brain connectivity between hippocampus and peri‐hippocampal cortex |
| المؤلفون: |
Lu, Yun, Li, Mingcong, Zhuang, Yuming, Lin, Ziyue, Nie, Binbin, Lei, Jianfeng, Zhao, Yuanyuan, Zhao, Hui |
| المساهمون: |
National Natural Science Foundation of China |
| المصدر: |
CNS Neuroscience & Therapeutics ; volume 30, issue 3 ; ISSN 1755-5930 1755-5949 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2023 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Aim The three‐phase enriched environment (EE) intervention paradigm has been shown to improve learning and memory function after cerebral ischemia, but the neuronal mechanisms are still unclear. This study aimed to investigate the hippocampal–cortical connectivity and the metabolic interactions between neurons and astrocytes to elucidate the underlying mechanisms of EE‐induced memory improvement after stroke. Methods Rats were subjected to permanent middle cerebral artery occlusion (pMCAO) or sham surgery and housed in standard environment or EE for 30 days. Memory function was examined by Morris water maze (MWM) test. Magnetic resonance imaging (MRI) was conducted to detect the structural and functional changes. [ 18 F]‐fluorodeoxyglucose (FDG) positron emission tomography (PET) was conducted to detect brain energy metabolism. PET‐based brain connectivity and network analysis was performed to study the changes of hippocampal–cortical connectivity. Astrocyte‐neuron metabolic coupling, including gap junction protein connexin 43 (Cx43), glucose transporters (GLUTs), and monocarboxylate transporters (MCTs), was detected by histological studies. Results Our results showed EE promoted memory function improvement, protected structure integrity, and benefited energy metabolism after stroke. More importantly, EE intervention significantly increased functional connectivity between the hippocampus and peri‐hippocampal cortical regions, and specifically regulated the level of Cx43, GLUTs and MCTs in the hippocampus and cortex. Conclusions Our results revealed the three‐phase enriched environment paradigm enhanced hippocampal–cortical connectivity plasticity and ameliorated post‐stroke memory deficits. These findings might provide some new clues for the development of EE and thus facilitate the clinical transformation of EE. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/cns.14466 |
| الإتاحة: |
https://doi.org/10.1111/cns.14466Test |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.7AF34816 |
| قاعدة البيانات: |
BASE |
