المؤلفون: Ahmad, Faraz S., Jackson, Kathryn L., Yount, Susan E., Rothrock, Nan E., Kallen, Michael A., Lacson, Leilani, Bilimoria, Karl Y., Kho, Abel N., Mutharasan, Raja Kannan, McCullough, Peter A., Bruckel, Jeffrey, Fedson, Savitri, Kimmel, Stephen E., Eton, David T., Grady, Kathleen L., Yancy, Clyde W., Cella, David

المساهمون: American Heart Association, National Heart, Lung, and Blood Institute, Agency for Healthcare Research and Quality

المصدر: ESC Heart Failure ; volume 9, issue 5, page 3380-3392 ; ISSN 2055-5822 2055-5822

الوصف: Aims Heart failure (HF) is a common and morbid condition impacting multiple health domains. We previously reported the development of the PROMIS®‐Plus‐HF (PROMIS+HF) profile measure, including universal and HF‐specific items. To facilitate use, we developed shorter, PROMIS+HF profiles intended for research and clinical use. Methods and results Candidate items were selected based on psychometric properties and symptom range coverage. HF clinicians ( n = 43) rated item importance and clinical actionability. Based on these results, we developed the PROMIS+HF‐27 and PROMIS+HF‐10 profiles with summary scores (0–100) for overall, physical, mental, and social health. In a cross‐sectional sample ( n = 600), we measured internal consistency reliability (Cronbach's alpha and Spearman–Brown), test–retest reliability (intraclass coefficient; n = 100), known‐groups validity via New York Heart Association (NYHA) class, and convergent validity with Kansas City Cardiomyopathy Questionnaire (KCCQ) scores. In a longitudinal sample ( n = 75), we evaluated responsiveness of baseline/follow‐up scores by calculating mean differences and Cohen's d and comparing with paired t ‐tests. Internal consistency was good to excellent ( α 0.82–0.94) for all PROMIS+HF‐27 scores and acceptable to good ( α /Spearman–Brown 0.60–0.85) for PROMIS+HF‐10 scores. Test–retest intraclass coefficients were acceptable to excellent (0.75–0.97). Both profiles demonstrated known‐groups validity for the overall and physical health summary scores based on NYHA class, and convergent validity for nearly all scores compared with KCCQ scores. In the longitudinal sample, we demonstrated responsiveness for PROMIS+HF‐27 and PROMIS+HF‐10 overall and physical summary scores. For the PROMIS+HF overall summary scores, a group‐based increase of 7.6–8.3 points represented a small to medium change (Cohen's d = 0.40–0.42). For the PROMIS+HF physical summary scores, a group‐based increase of 5.0–5.9 points represented a small to medium change (Cohen's d = 0.29–0.35). ...

الإتاحة: https://doi.org/10.1002/ehf2.14061Test

المؤلفون: Imhof, Reese L., Eton, David T., Tollefson, Megha M.

المصدر: Pediatric Dermatology ; volume 40, issue 5, page 860-862 ; ISSN 0736-8046 1525-1470

الوصف: We used the Psoriasis Caregiver Impact Scale to explore the quality of life (QoL) of parents/caregivers of children with psoriasis. We found that the QoL of parents of children with psoriasis is negatively affected in numerous domains including family and social life, emotional health, work, activities, and finances.

الإتاحة: https://doi.org/10.1111/pde.15382Test

المؤلفون: Jensen, Roxanne E., Moinpour, Carol M., Potosky, Arnold L., Lobo, Tania, Hahn, Elizabeth A., Hays, Ron D., Cella, David, Smith, Ashley Wilder, Wu, Xiao‐Cheng, Keegan, Theresa H. M., Paddock, Lisa E., Stroup, Antoinette M., Eton, David T.

المساهمون: National Institutes of Health, National Center for Research Resources, National Center for Advancing Translational Sciences

المصدر: Cancer ; volume 123, issue 2, page 327-335 ; ISSN 0008-543X 1097-0142

الوصف: BACKGROUND The Patient‐Reported Outcomes Measurement Information System (PROMIS) was a National Institutes of Health‐funded initiative to develop measures of symptoms and function. Responsiveness is the degree to which a measure can detect underlying changes over time. The objective of the current study was to document the responsiveness of 8 PROMIS measures in a large, population‐based cancer cohort. METHODS The Measuring Your Health study recruited 2968 patients who were diagnosed with 1 of 7 cancers between 2010 and 2012 through 4 Surveillance, Epidemiology, and End Results registries. Participants completed a baseline survey (6‐13 months after diagnosis) and a 6‐month follow‐up survey. Changes in 8 PROMIS scores were compared with global ratings of transition, changes in performance status, and clinical events. RESULTS Measures were responsive to 6‐month declines and improvements in performance status with small to large effect sizes (ES) (Cohen d = 0.34‐0.71; P < .01). Mean changes and effect sizes were larger for participants who reported declines compared with those who reported improvements. Small‐to‐medium ES were observed in patients who reported being “a little” worse (d = 0.31‐0.56), and medium‐to‐large ES were observed in those who reported being “a lot” worse (d = 0.53‐0.72). Hospitalized participants reported significant score increases, resulting in worsening of pain (d = 0.51), fatigue (d = 0.35), and depression (d = 0.57; all P < .01). Cancer recurrence and progression were associated with smaller increases in pain, fatigue, and sleep disturbance (d = 0.22‐0.27). CONCLUSIONS The current results indicated that all 8 PROMIS measures were sensitive to patient‐perceived worsening and improvement and to major clinical events. These findings will be able to inform the design and interpretation of future research studies and clinical initiatives administering PROMIS measures. Cancer 2017;123:327–335. © 2016 American Cancer Society .

الإتاحة: https://doi.org/10.1002/cncr.30354Test

المؤلفون: Eton, David T., Lepore, Stephen J., Helgeson, Vicki S.

المصدر: Cancer ; volume 103, issue 11, page 2412-2418 ; ISSN 0008-543X 1097-0142

الوصف: BACKGROUND The authors examined levels and predictors of psychological distress in the wives of men treated for early‐stage prostate carcinoma (PCa). METHODS Patients with PCa ( N = 165) and spouses were interviewed to assess general and cancer‐specific distress. Social and intrapersonal factors of spouses as well as clinical characteristics and quality of life of patients were assessed as potential predictors of spouses' distress. RESULTS Spouses reported more cancer‐specific distress than did patients ( P < 0.001), but did not differ from patients in general distress. Several spouse‐reported factors predicted higher spouses' distress, including less education ( P < 0.005), worse marriage quality and less social support ( P s < 0.005), more negative social interaction with the patient ( P s < 0.001), lower self‐esteem ( P s < 0.001), less positive coping ( P s < 0.005), searching for meaning ( P < 0.001), not finding meaning ( P < 0.005), and greater illness uncertainty ( P s < 0.001). Patients' bowel function and mental health also predicted greater spouses' distress ( P s < 0.005). CONCLUSIONS The findings indicated that overall distress in spouses of early‐stage patients with PCa was modest, and it was more likely to be predicted by psychosocial than medical factors. Cancer 2005. © 2005 American Cancer Society.

الإتاحة: https://doi.org/10.1002/cncr.21092Test

المؤلفون: Darling, Gail, Eton, David T., Sulman, Joanne, Casson, Alan G., Cella, David

المصدر: Cancer ; volume 107, issue 4, page 854-863 ; ISSN 0008-543X 1097-0142

الوصف: BACKGROUND. To develop and validate a quality of life subscale for patients with esophageal cancer to be used with the Functional Assessment of Cancer Therapy—General (FACT‐G). METHODS. Prospective cohort study of patients with esophageal cancer treated with surgery alone or neoadjuvant chemoradiotherapy and surgery evaluating the validity, internal consistency, and responsiveness to change of the FACT‐Esophageal (FACT‐E) when comparing it with the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ 30) and esophageal (OES 24) as well as clinical factors. RESULTS. The FACT‐E demonstrated very good convergent and divergent validity when compared with the EORTC QLQ30 and OES 24 and clinical variables. Internal consistency was also good with coefficient α >0.70 for all subscales and individual items. Stability coefficients were >0.80. Changes in clinical status were reflected in changes in FACT‐E scores demonstrating responsiveness to change, particularly in patients receiving neoadjuvant chemoradiotherapy before surgery. CONCLUSIONS. The FACT‐E met or exceeded all standards for validity, providing an option to measure health‐related quality of life for different treatment strategies for esophageal cancer. Cancer 2006. © 2006 American Cancer Society.

الإتاحة: https://doi.org/10.1002/cncr.22055Test

المؤلفون: Eton, David T., Lepore, Stephen J.

المصدر: Psycho-Oncology ; volume 11, issue 4, page 307-326 ; ISSN 1057-9249 1099-1611

الوصف: With the established effectiveness of diverse treatments for prostate cancer, identification of the physical and psychosocial consequences of the disease and various treatments becomes critical. We review the literature on the effects of prostate cancer and its treatment on health‐related quality of life (HRQoL). Studies show that prostate cancer and its treatment affect both disease‐specific HRQoL (i.e. urinary, sexual, and bowel function) as well as general HRQoL (i.e. energy/vitality, performance in physical and social roles). Yet, these effects appear to differ across stage of disease and type of treatment. We outline evidence from three sources: (1) studies that compare men with the disease with an age‐matched sample of men without the disease, (2) studies that assess men with the disease across time, and (3) cross‐sectional studies that highlight predictors of HRQoL. Future research directions are discussed. Copyright © 2002 John Wiley & Sons, Ltd.

الإتاحة: https://doi.org/10.1002/pon.572Test

المؤلفون: Eton, David T., Lepore, Stephen J., Helgeson, Vicki S.

المصدر: Cancer ; volume 92, issue 6, page 1451-1459 ; ISSN 0008-543X 1097-0142

الإتاحة: https://doi.org/10.1002/1097-0142Test(20010915)92:6%3C1451::aid-cncr1469%3E3.0.co%3B2-r