التفاصيل البيبلوغرافية
| العنوان: |
Comparison of transfusion requirements in adult patients undergoing Haploidentical or single‐unit umbilical cord blood stem cell transplantation |
| المؤلفون: |
Solves, Pilar, Sanz, Jaime, Gómez, Inés, de la Puerta, Rosalía, Arnao, Mario, Montoro, Juan, Piñana, José Luis, Carretero, Carlos, Balaguer, Aitana, Guerreiro, Manuel, Andreu, Rafa, Rodríguez, Rebeca, Montesinos, Pau, Jarque, Isidro, Lorenzo, José Ignacio, Carpio, Nelly, Sanz, Miguel Ángel, Sanz, Guillermo Francisco |
| المصدر: |
European Journal of Haematology ; volume 103, issue 3, page 172-177 ; ISSN 0902-4441 1600-0609 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2019 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Objectives Umbilical cord blood transplantation (UCBT) and haploidentical hematopoietic stem cell transplantation (haplo‐HSCT) modalities have been developed to offset the lack of matched donors. In this study, we compare the transfusion requirements of patients undergoing UCBT and haplo‐HSCT in a single institution with the aim of providing additional information for clinicians to choose the most adequate alternative graft for HSCT. Methods The study reviewed 67 and 46 patients undergoing UCBT and haplo‐HSCT, respectively. Results There were no significant differences for RBC and PLT requirements according to the transplantation modality. Median time to RBC transfusion independence was 35 and 25.5 days in patients who received an UCBT and haplo‐HSCT, respectively ( P = 0.38), while median time to platelet transfusion independence was 31 days for UCBT patients and 23 for haplo‐HSCT patients ( P < 0.001). Days until neutrophils > 0.5 × 10 9 /L were the only variable that significantly influenced RBC and PLT requirements for both transplantation modalities. Cumulative incidence of RBC and PLT transfusion independence at 90 days after transplantation was similar for both UCBT and haplo‐HSCT. Conclusions Both transplantation platforms require prolonged and intensive supportive RBC and PLT transfusion therapy. Both transplantation platforms require prolonged and intensive supportive RBC and PLT transfusion therapy. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/ejh.13270 |
| الإتاحة: |
https://doi.org/10.1111/ejh.13270Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.8158272D |
| قاعدة البيانات: |
BASE |
