رسالة جامعية
Mechanisms by which hypoxia augments Leydig cell viability and differentiated cell function in vitro
| العنوان: | Mechanisms by which hypoxia augments Leydig cell viability and differentiated cell function in vitro |
|---|---|
| المؤلفون: | Kukucka, Mark A. |
| المساهمون: | Veterinary Medical Sciences, Misra, Hara P., Caceci, Thomas, Gwazdauskas, Francis C., Pfeiffer, Carl J., Keith, James C. Jr. |
| بيانات النشر: | Virginia Tech |
| سنة النشر: | 1993 |
| المجموعة: | VTechWorks (VirginiaTech) |
| مصطلحات موضوعية: | antioxidant, free radical toxicology, LD5655.V856 1993.K858, Cell differentiation, Cellular control mechanisms, Leydig cells, Oxytocin -- Research |
| الوصف: | The 1980's heralded the discovery and identification of extra-pituitary sources of the neurohypophysial hormone oxytocin in non-neural tissues of several animal species. The presence, location and biosynthesis of significant amounts of oxytocin in the ovarian corpus luteum was followed by the immunocytochemical demonstration of an oxytocin-like peptide in the testicular interstitial cells. Leydig cells, which comprise up to 80% of the testicular intertubular cell population, are known to synthesize testosterone in situ. Indirect evidence indicated that an oxytocin-like peptide was also present in Leydig cells. The question arose whether this peptide was synthesized de novo by Leydig cells or was taken up and stored by the cells following biosynthesis at some other intra- and/or extra-gonadal source(s). Since luteinizing hormone (LH) and ascorbate are known to augment the production of oxytocin in ovarian granulosa cells, varying concentrations of these two stimulants were used to monitor the biosynthesis of oxytocin from isolated Leydig cells in culture. ; Ph. D. |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| وصف الملف: | xix, 171 leaves; BTD; application/pdf |
| اللغة: | English |
| العلاقة: | OCLC# 28529198; LD5655.V856_1993.K858.pdf; etd-06062008-170416; http://hdl.handle.net/10919/38407Test; http://scholar.lib.vt.edu/theses/available/etd-06062008-170416Test/ |
| الإتاحة: | http://hdl.handle.net/10919/38407Test http://scholar.lib.vt.edu/theses/available/etd-06062008-170416Test/ |
| حقوق: | In Copyright ; http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.8AFB9634 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |