دورية أكاديمية
Transport and Metabolism Behavior of Brazilein during Its Entrance into Neural Cells ; PLOS ONE
| العنوان: | Transport and Metabolism Behavior of Brazilein during Its Entrance into Neural Cells ; PLOS ONE |
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| المؤلفون: | Zhao, Shuang, Wang, Xin-Pei, Jiang, Jing-Fei, Chai, Yu-Shuang, Tian, Yu, Feng, Tian-Shi, Ding, Yi, Huang, Jing, Lei, Fan, Xing, Dong-Ming, Du, Li-Jun |
| المساهمون: | Chemistry |
| بيانات النشر: | PLOS |
| سنة النشر: | 2014 |
| المجموعة: | VTechWorks (VirginiaTech) |
| الوصف: | Brazilein, a natural small molecule, shows a variety of pharmacological activities, especially on nervous system and immune system. As a potential multifunctional drug, we studied the distribution and the transport behavior and metabolic behavior of brazilein in vivo and in vitro. Brazilein was found to be able to distribute in the mouse brain and transport into neural cells. A metabolite was found in the brain and in the cells. Positive and negative mode-MS/MS and Q-TOF were used to identify the metabolite. MS/MS fragmentation mechanisms showed the methylation occurred at the10-hydroxyl of brazilein (10-O-methylbrazilein). Further, catechol-O- methyltransferase (COMT) was confirmed as a crucial enzyme correlated with the methylated metabolite generation by molecular docking and pharmacological experiment. ; Published version |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | e108000; http://hdl.handle.net/10919/85218Test; https://doi.org/10.1371/journal.pone.0108000Test; 10 |
| DOI: | 10.1371/journal.pone.0108000 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0108000Test http://hdl.handle.net/10919/85218Test |
| حقوق: | Creative Commons Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.82682F9A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0108000 |