دورية أكاديمية
Prediabetes Phenotype Influences Improvements in Glucose Homeostasis with Resistance Training ; PLOS ONE
| العنوان: | Prediabetes Phenotype Influences Improvements in Glucose Homeostasis with Resistance Training ; PLOS ONE |
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| المؤلفون: | Eikenberg, Joshua D., Savla, Jyoti S., Marinik, Elaina L., Davy, Kevin P., Pownall, John, Baugh, Mary Elizabeth, Flack, Kyle D., Boshra, Soheir, Winett, Richard A., Davy, Brenda M. |
| بيانات النشر: | PLOS |
| سنة النشر: | 2016 |
| المجموعة: | VTechWorks (VirginiaTech) |
| مصطلحات موضوعية: | impaired fasting glucose, type-2 diabetes-mellitus, life-style intervention, randomized controlled-trial, glycemic control, insulin sensitivity, skeletal-muscle, sample-size, tolerance, exercise |
| الوصف: | Purpose To determine if prediabetes phenotype influences improvements in glucose homeostasis with resistance training (RT). Methods Older, overweight individuals with prediabetes (n = 159; aged 605 yrs; BMI 334 kg/m2) completed a supervised RT program twice per week for 12 weeks. Body weight and composition, strength, fasting plasma glucose, 2-hr oral glucose tolerance, and Matsuda-Defronza estimated insulin sensitivity index (ISI) were assessed before and after the intervention. Participants were categorized according to their baseline prediabetes phenotype as impaired fasting glucose only (IFG) (n = 73), impaired glucose tolerance only (IGT) (n = 21), or combined IFG and IGT (IFG/IGT) (n = 65). Results Chest press and leg press strength increased 27% and 18%, respectively, following the 12-week RT program (both p<0.05). Waist circumference (-1.0%; pre 109.310.3 cm, post 108.210.6 cm) and body fat (-0.6%; pre 43.76.8%, post 43.16.8%) declined, and lean body mass (+1.3%; pre 52.010.4 kg, post 52.710.7 kg) increased following the intervention. Fasting glucose concentrations did not change (p>0.05) following the intervention. However, 2-hr oral glucose tolerance improved in those with IGT (pre 8.940.72 mmol/l, post 7.831.11 mmol/l, p<0.05) and IFG/IGT (pre 9.661.11mmol/l, post 8.602.00 mmol/l) but not in those with IFG (pre 6.271.28mmol/l, post 6.33 1.55 mmol/l). There were no significant changes in ISI or glucose area under the curve following the RT program. Conclusions RT without dietary intervention improves 2-hr oral glucose tolerance in individuals with prediabetes. However, the improvements in glucose homeostasis with RT appear limited to those with IGT or combined IFG and IGT. ; Published version |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ? - ? (13) page(s); application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000369550200075&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1Test; http://hdl.handle.net/10919/74015Test; https://doi.org/10.1371/journal.pone.0148009Test; 11 |
| DOI: | 10.1371/journal.pone.0148009 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0148009Test http://hdl.handle.net/10919/74015Test |
| حقوق: | Creative Commons Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.C5B177FD |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0148009 |