دورية أكاديمية
Risk factors and titers of COVID-19 infection in a longitudinal statewide seroepidemiology cohort ; BMC Infectious Diseases
| العنوان: | Risk factors and titers of COVID-19 infection in a longitudinal statewide seroepidemiology cohort ; BMC Infectious Diseases |
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| المؤلفون: | Rogawski McQuade, Elizabeth T., Becker, Lea, Stroup, Suzanne E., Khan, Fauzia, Shah, Bhruga, Brush, John, Goldsmith, Gay, Mullin, Rebecca, Guilliams, Danielle, deFilippi, Christopher, Barackman, Kathleen, Mohr, Andrea B., Farrell, Frances, Bearman, Gonzalo, Peake, Lilian, Houpt, Eric R. |
| بيانات النشر: | Springer |
| سنة النشر: | 2023 |
| المجموعة: | VTechWorks (VirginiaTech) |
| مصطلحات موضوعية: | COVID-19, Nucleocapsid, Risk factors, SARS-CoV-2, Seroepidemiology, Spike, Vaccine, Humans, Antibodies, Viral, Longitudinal Studies, Seroepidemiologic Studies, Adult, Middle Aged, Child, Virginia, Neutralizing, COVID-19 Vaccines |
| الوصف: | Background: Virginia is a large state in the USA, yet it remains unclear what percentage of the population has had natural COVID-19 infection and whether risk factors for infection have changed over time. Methods: Using a longitudinal cohort, from December 2021-July 2022 we performed follow up serology and a questionnaire on 784 individuals from across Virginia who had previously participated in a statewide COVID-19 seroepidemiology study in 2020. Children were also invited to participate and an additional 62 children also completed the study. Serology was performed using Roche nucleocapsid and spike serological assays. Results: The majority of participants were white (78.6%), over 50 years old (60.9%), and reported having received COVID-19 vaccine (93.4%). 28.6% had evidence of prior COVID-19 infection (nucleocapsid positive). Reweighted by region, age, and sex to match the Virginia census data, the seroprevalence of nucleocapsid antibodies was estimated to be 30.6% (95% CI: 24.7, 36.6). We estimated that 2553% of COVID-19 infections were asymptomatic. Infection rates were lower in individuals > 60 years old and were higher in Blacks and Hispanics. Infection rates were also higher in those without health insurance, in those with greater numbers of household children, and in those that reported a close contact or having undergone quarantine for COVID-19. Participants from Southwest Virginia had lower seropositivity (16.2%, 95% CI 6.5, 26.0) than other geographic regions. Boosted vaccinees had lower infection rates than non-boosted vaccinees. Frequenting indoor bars was a risk factor for infection, while frequently wearing an N95 mask was protective, though the estimates of association were imprecise. Infection rates were higher in children than adults (56.5% vs. 28.6%). Infection in the parent was a risk factor for child infection. Spike antibody levels declined with time since last vaccination, particularly in those that were vaccinated but not previously infected. Neutralizing antibody positivity was high ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1471-2334 |
| العلاقة: | https://www.ncbi.nlm.nih.gov/pubmed/37821853Test; 676 (Article number); https://hdl.handle.net/10919/117320Test; https://doi.org/10.1186/s12879-023-08670-6Test; 23; Farrell, Frances [0000-0002-8105-1015] |
| DOI: | 10.1186/s12879-023-08670-6 |
| الإتاحة: | https://doi.org/10.1186/s12879-023-08670-6Test https://hdl.handle.net/10919/117320Test |
| حقوق: | Creative Commons Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.F8B9F68A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14712334 |
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| DOI: | 10.1186/s12879-023-08670-6 |