دورية أكاديمية
The first insight into the genetic structure of the population of modern Serbia
| العنوان: | The first insight into the genetic structure of the population of modern Serbia |
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| المؤلفون: | Drljača, Tamara, Zukić, Branka, Kovačević, Vladimir, Gemović, Branislava S., Karan-Đurašević, Teodora, Perović, Vladimir R., Lazarević, Mladen, Pavlović, Sonja, Veljković, Nevena V. |
| المصدر: | Scientific Reports |
| سنة النشر: | 2021 |
| المجموعة: | VinaR Repository (Vinča Institute of Nuclear Sciences / University of Belgrade) |
| الوصف: | The complete understanding of the genomic contribution to complex traits, diseases, and response to treatments, as well as genomic medicine application to the well-being of all humans will be achieved through the global variome that encompasses fine-scale genetic diversity. Despite significant efforts in recent years, uneven representation still characterizes genomic resources and among the underrepresented European populations are the Western Balkans including the Serbian population. Our research addresses this gap and presents the first ever targeted sequencing dataset of variants in clinically relevant genes. By measuring population differentiation and applying the Principal Component and Admixture analysis we demonstrated that the Serbian population differs little from other European populations, yet we identified several novel and more frequent variants that appear as its unique genetic determinants. We explored thoroughly the functional impact of frequent variants and its correlation with the health burden of the population of Serbia based on a sample of 144 individuals. Our variants catalogue improves the understanding of genetics of modern Serbia, contributes to research on ancestry, and aids in improvements of well-being and health equity. In addition, this resource may also be applicable in neighboring regions and valuable in worldwide functional analyses of genetic variants in individuals of European descent. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 2045-2322 |
| العلاقة: | Ministry of Education, Science and Technological Development, Republic of Serbia; https://vinar.vin.bg.ac.rs/handle/123456789/10769Test; 000674547300003; 2-s2.0-85109419642; http://vinar.vin.bg.ac.rs/bitstream/id/28494/bitstream_78653.pdfTest |
| DOI: | 10.1038/s41598-021-93129-4 |
| الإتاحة: | https://doi.org/10.1038/s41598-021-93129-4Test https://vinar.vin.bg.ac.rs/handle/123456789/10769Test http://vinar.vin.bg.ac.rs/bitstream/id/28494/bitstream_78653.pdfTest |
| حقوق: | openAccess ; https://creativecommons.org/licenses/by/4.0Test/ ; BY |
| رقم الانضمام: | edsbas.2655037F |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-021-93129-4 |