التفاصيل البيبلوغرافية
| العنوان: |
Matrix metalloproteinases-2, -7 and tissue metalloproteinase inhibitor-1 expression in human endometrium |
| المؤلفون: |
Grzechocinska, Barbara, Dabrowski, Filip A., Cyganek, Anna, Chlebus, Marcin, Kobierzycki, Christopher, Michalowski, Lukasz, Gornicka, Barbara, Wielgos, Miroslaw |
| المساهمون: |
1st Faculty of Medicine, Medical University of Warsaw |
| المصدر: |
Folia Histochemica et Cytobiologica; Vol 56, No 3 (2018); 133-140 |
| بيانات النشر: |
Via Medica |
| سنة النشر: |
2018 |
| المجموعة: |
Via Medica Journals |
| مصطلحات موضوعية: |
metalloproteinase, MMP, tissue inhibitor of metalloproteinase, TIMP, endometrium, estradiol, progesterone, 00.04 Urogenital System, 00.09.02 Epithelium, 10.1.1 Human |
| الوصف: |
Introduction. Endometrium undergoes regular, cyclic tissue remodeling mostly associated to the endocrine system status. It is well-known fact that steroid hormones are strongly responsible for changes in endometrium. The precise mechanism of their action is still under investigation. The aim of the study was to evaluate the expression of metalloproteinases 2 and 7 (MMP-2, -7) and tissue inhibitor of metalloproteinase 1 (TIMP-1) in human endometrium in relation to serum concentrations of estradiol and progesterone during different phases of menstrual cycle.Material and methods. The study material consisted of 52 biopsy samples; 12 obtained in the proliferative phase, 11 in the secretory phase and 29 during menstruation. Expression of MMP-2, MMP-7 and TIMP-1 was assessed by immunohistochemistry. Serum concentrations of estradiol and progesterone at time of biopsy were evaluated by immunochemistry assay. Results of the study were statistically assessed by linear regression model.Results. Increased serum concentration of estradiol was associated with increased MMP-2 expression in proliferative phase but decreased in secretory phase and during menstruation. No significant relationship was found between progesterone concentration and MMP-2 expression. Moreover, no difference in the expression of MMP-7 and TIMP-1 in the endometrium in relation to hormone levels and menstrual cycle phases were observed.Conclusions. The results of the study indicate that estradiol influence MMP-2 expression in the endometrium depends on the phase of menstrual cycle. Such relationships were not found for MMP-7 and TIMP-1 and further tests clarifying association between estradiol and MMPs are needed. |
| نوع الوثيقة: |
other/unknown material |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://journals.viamedica.pl/folia_histochemica_cytobiologica/article/view/FHC.a2018.0017Test |
| DOI: |
10.5603/FHC.a2018.0017 |
| الإتاحة: |
https://doi.org/10.5603/FHC.a2018.0017Test
https://journals.viamedica.pl/folia_histochemica_cytobiologica/article/view/FHC.a2018.0017Test |
| حقوق: |
By sending the manuscript with figures and charts the author (authors) declares (declare) it has been neither published nor submitted to the Editorial Board of any other journal (not including the abstracts 400 words or less). Moreover, it is assumed that the copyright for publishing and distribution of the submitted material (in all known now and developed in the future forms and fields of exploitation) are automatically and free-of-charge transferred to the Polish Histochemical and Cytochemical Society, under condition that those materials are accepted for publication. The authors accept the fact, that the work will not be published anywhere and in any language without the prior written consent of the owner of the copyrights, i.e. the Polish Histochemical and Cytochemical Society. Independently to the formerly mentioned effects, author (authors) due to release form the responsibilities to the third parties, shall (should) attach the cover letter to the manuscript. The cover letter shall contain declaration of the author (authors) confirming formerly described facts and that all co-authors of the manuscript agree for the publication. Moreover the author (authors) confirm that they have acquaint themselves with the editorial policy in “Folia Histochemica et Cytobiologica” and they oblige to respect the policy. The reward for sending the manuscript is publication in the journal. The written permission from the previous Polish Histochemical and Cytochemical Society for the reprint should be enclosed to the materials (pictures, photos, figures, etc.) that have been printed previously. If the data presented in case reports, figures or in the text enable identification of the persons their written consent to the publication should be enclosed. Any potential conflict of interest will be dealt with by the local court specific to the Polish Histochemical and Cytochemical Society. Legal relations between the Polish Histochemical and Cytochemical Society and the author(s) are in accordance with Polish law and with international conventions binding to Poland. The legal bases to acquiring the copyright are article 921 section 3 sentence 3 of the civil code in connection with article 50 of the copyright law and related law as well as the international conventions binding to Poland. © Polish Histochemical and Cytochemical Society |
| رقم الانضمام: |
edsbas.6AB001AC |
| قاعدة البيانات: |
BASE |
