التفاصيل البيبلوغرافية
| العنوان: |
P2Y12 inhibitor monotherapy in complex percutaneous coronary intervention: A post-hoc analysis of SMART-CHOICE randomized clinical trial |
| المؤلفون: |
Roh, Ji Woong, Hahn, Joo-Yong, Oh, Ju-Hyeon, Chun, Woo Jung, Park, Yong Hwan, Jang, Woo Jin, Im, Eul-Soon, Jeong, Jin-Ok, Cho, Byung Ryul, Oh, Seok Kyu, Yun, Kyeong Ho, Cho, Deok-Kyu, Lee, Jong-Young, Koh, Young-Youp, Bae, Jang-Whan, Choi, Jae Woong, Lee, Wang Soo, Yoon, Hyuck Jun, Lee, Seung Uk, Cho, Jang Hyun, Choi, Woong Gil, Rha, Seung-Woon, Kim, Hee-Yeol, Lee, Joo Myung, Park, Taek Kyu, Yang, Jeong Hoon, Choi, Jin-Ho, Choi, Seung-Hyuck, Lee, Sang Hoon, Gwon, Hyeon-Cheol, Kim, Dong-Bin, Song, Young Bin |
| المصدر: |
Cardiology Journal; Vol 28, No 6 (2021); 855-863 |
| بيانات النشر: |
Via Medica |
| سنة النشر: |
2021 |
| المجموعة: |
Via Medica Journals |
| مصطلحات موضوعية: |
clopidogrel, high-risk, percutaneous coronary intervention |
| الوصف: |
Background: It remains unclear whether P2Y12 monotherapy, especially clopidogrel, following short-duration dual antiplatelet therapy (DAPT) is associated with favorable outcomes in patients undergoing complex percutaneous coronary intervention (PCI). Therefore, this study analyzed the efficacy and safety of P2Y12 inhibitor monotherapy, mostly clopidogrel (78%), in complex PCI following short-term DAPT.Methods: The post-hoc analysis of the SMART-CHOICE trial involving 2,993 patients included 498 cases of complex PCIs, defined by at least one of the following features: 3 vessels treated, ≥ 3 stents implanted, ≥ 3 lesions treated, bifurcation with ≥ 2 stents implanted, and a total stent length of ≥ 60 mm. The primary endpoint was major adverse cardiac and cerebrovascular event (MACCE), defined as the composite of all-cause death, myocardial infarction, and stroke. The primary safety endpoint included bleeding, defined as Bleeding Academic Research Consortium (BARC) types 2 to 5.Results: Complex PCI group had a higher risk of MACCE (4.0% vs. 2.3%, hazard ratio [HR] = 1.74, 95% confidence interval [CI]: 1.05–2.89, p = 0.033) and a similar risk of BARC types 2–5 bleeding (2.6% vs. 2.6%, HR = 1.02, 95% CI: 0.56–1.86, p = 0.939) compared with those without complex PCIs. Patients undergoing complex PCIs, followed by P2Y12 inhibitor monotherapy and 12 months of DAPT exhibited similar rates of MACCE (3.8% vs. 4.2%, HR = 0.92, 95% CI: 0.38–2.21, p = 0.853).Conclusions: P2Y12 inhibitor monotherapy, mostly clopidogrel, following 3 months of DAPT did not increase ischemic events in patients with complex PCIs. |
| نوع الوثيقة: |
other/unknown material |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://journals.viamedica.pl/cardiology_journal/article/downloadSuppFile/84704/312102Test; https://journals.viamedica.pl/cardiology_journal/article/view/CJ.a2021.0101Test |
| DOI: |
10.5603/CJ.a2021.0101 |
| الإتاحة: |
https://doi.org/10.5603/CJ.a2021.0101Test
https://journals.viamedica.pl/cardiology_journal/article/view/CJ.a2021.0101Test |
| حقوق: |
Completion of the online submission form electronically is tantamount to automatically and free-of-charge transferring of the copyright for publishing and distribution of the submitted material (in all known now and developed in the future forms and fields of exploitation) to the Publisher, under condition that those materials are accepted for publication. The authors agree not to publish any data or figures presented in their work anywhere and in any language without the prior written consent of the owner of the copyrights, i.e. the Publisher. |
| رقم الانضمام: |
edsbas.15B7C030 |
| قاعدة البيانات: |
BASE |
