التفاصيل البيبلوغرافية
| العنوان: |
High sensitive TROponin levels In Patients with Chest pain and kidney disease: A multicenter registry — The TROPIC study |
| المؤلفون: |
Ballocca, Flavia, D'Ascenzo, Fabrizio, Moretti, Claudio, Diletti, Roberto, Budano, Carlo, Palazzuoli, Alberto, Reed, Matthew J., Palmerini, Tullio, Dudek, Dariusz, Galassi, Alfredo, Omedè, Pierluigi, Mieghem, Nicolas M., Ferenbach, David, Pavani, Marco, Della Riva, Diego, Mills, Nick L., Van Domburgh, Ron T., Mariani, Andrea, Dziewierz, Artur, di Cuia, Marco, Jan van Geuns, Robert, Zijlstra, Felix, Bergerone, Serena, Marra, Sebastiano, Biondi Zoccai, Giuseppe, Gaita, Fiorenzo |
| المصدر: |
Cardiology Journal; Vol 24, No 2 (2017); 139-150 |
| بيانات النشر: |
Via Medica |
| سنة النشر: |
2017 |
| المجموعة: |
Via Medica Journals |
| مصطلحات موضوعية: |
high sensitive troponin, chronic kidney disease, coronary artery disease |
| الوصف: |
Background: Accuracy of high sensitive troponin (hs-cTn) to detect coronary artery disease (CAD) in patients with renal insufficiency is not established. The aim of this study was to evaluate the prognostic role of hs-cTn T and I in patients with chronic kidney disease (CKD). Methods: All consecutive patients with chest pain, renal insufficiency (eGFR < 60 mL/min/1.73 m2) and high sensitive troponin level were included. The predictive value of baseline and interval troponin (hs-cTnT and hs-cTnI) for the presence of CAD was assessed. Results: One hundred and thirteen patients with troponin I and 534 with troponin T were included, with 95 (84%) and 463 (87%) diagnosis of CAD respectively. There were no differences in clinical, procedural and outcomes between the two assays. For both, baseline hs-cTn values did not differ between patients with/without CAD showing low area under the curve (AUC). For interval levels, hs-cTnI was significantly higher for patients with CAD (0.2 ± 0.8 vs. 8.9 ± 4.6 ng/mL; p = 0.04) and AUC was more accurate for troponin I than hs-cTnT (AUC 0.85 vs. 0.69). Peak level was greater for hs-cTnI in patients with CAD or thrombus (0.4 ± 0.6 vs. 15 ± 20 ng/mL; p = 0.02; AUC 0.87: 0.79–0.93); no differences were found for troponin T assays (0.8 ± 1.5 vs. 2.2 ± 3.6 ng/mL; p = 1.7), with lower AUC (0.73: 0.69–0.77). Peak troponin levels (both T and I) independently predicted all cause death at 30 days. Conclusions: Patients with CKD presenting with altered troponin are at high risk of coronary disease. Peak level of both troponin assays predicts events at 30 days, with troponin I being more accurate than troponin T. (Cardiol J 2017; 24, 2: 139–150) |
| نوع الوثيقة: |
other/unknown material |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://journals.viamedica.pl/cardiology_journal/article/view/CJ.a2017.0025Test |
| DOI: |
10.5603/CJ.a2017.0025 |
| الإتاحة: |
https://doi.org/10.5603/CJ.a2017.0025Test
https://journals.viamedica.pl/cardiology_journal/article/view/CJ.a2017.0025Test |
| حقوق: |
Completion of the online submission form electronically is tantamount to automatically and free-of-charge transferring of the copyright for publishing and distribution of the submitted material (in all known now and developed in the future forms and fields of exploitation) to the Publisher, under condition that those materials are accepted for publication. The authors agree not to publish any data or figures presented in their work anywhere and in any language without the prior written consent of the owner of the copyrights, i.e. the Publisher. |
| رقم الانضمام: |
edsbas.9408462D |
| قاعدة البيانات: |
BASE |
