التفاصيل البيبلوغرافية
| العنوان: |
Brazilian pediatric patients with gliomas: treatment characteristics and survival outcomes |
| المؤلفون: |
Starling, Maria Thereza Mansur, Pereira, Allan Andresson Lima, Viani, Gustavo, Paiva, Wellingson Silva, Neville, Iuri Santana, Restini, Felipe Cicci Farinha, Gouveia, Andre Guimaraes, Penido Mendes de Sousa, Cecilia Félix, Maldaun, Marcos Vinícius Calfat, Pahl, Felix Hendrik, Hanna, Samir A., Moraes, Fabio Ynoe, Marta, Gustavo Nader |
| المصدر: |
Reports of Practical Oncology and Radiotherapy; Vol 29, No 1 (2024); 90-96 |
| بيانات النشر: |
Via Medica |
| سنة النشر: |
2024 |
| المجموعة: |
Via Medica Journals |
| مصطلحات موضوعية: |
pediatric brain neoplasia, treatment, prognosis, survival |
| الوصف: |
Background: The current study aimed to determine the overall survival (OS) rates of patients diagnosed with pediatric gliomas in Brazil, accounting for the influence of age, treatment modalities, and tumor site, using a population-based national database. Materials and methods: Patients diagnosed with pediatric gliomas of central nervous system (CNS) from 1999–2020 were identified from The Fundação Oncocentro de São Paulo public database. The Kaplan-Meier and the log-rank test were used for survival analysis. Results: A total of 1296 patients were included. The most common histologic tumor types were glioblastomas (38.27%; n = 496), pilocytic astrocytoma (32.87%; n = 426), and astrocytoma grade II (20.76%; n = 269). A total of 379 (29.24%) had brainstem tumors. The mean follow-up was 135 months [95% confidence interval (CI): 128–142]. The 1-year, 3-year 5-year OS for pilocytic astrocytoma were 93.72%, 89.98%, and 88.97%; for grade II gliomas, 80.36%, 71.89%, and 68.60%; for grade III gliomas, 53.72%; 31.87%, and 28.33%; and for glioblastoma, 52.90%, 28.76%, 25.20%, respectively. Brainstem tumors had the worse OS compared to no brainstem tumors (p = 0.001). For high-grade glioma (grade III/IV), excluding brainstem tumors (n = 570), young patients had greater median OS (0 to 3 years:22 months; 4 to 18 years:13 months; p = 0.005). Regarding the treatment modalities, combined treatments were associated with higher median survival compared to less intensive therapy (surgery: 11 months; surgery and chemotherapy: 16 months; surgery, radiotherapy, and chemotherapy: 20 months; p=0.005). Conclusion: In our cohort, low-grade gliomas had favorable prognoses and outcomes. Patients diagnosed with glioblastomas and brainstem gliomas had the worst OS. For high-grade gliomas, undergoing treatment de-intensification in the Brazilian pediatric population is associated with worse survival. |
| نوع الوثيقة: |
other/unknown material |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://journals.viamedica.pl/rpor/article/downloadSuppFile/99356/419137Test; https://journals.viamedica.pl/rpor/article/view/99356Test |
| DOI: |
10.5603/rpor.99356 |
| الإتاحة: |
https://doi.org/10.5603/rpor.99356Test
https://journals.viamedica.pl/rpor/article/view/99356Test |
| حقوق: |
Completion of the online submission form electronically (the Author's Statement) is tantamount to automatic transfer of the copyright for publishing and distribution of the submitted material (in all current and future forms and fields of exploitation) to the Copyright Owner, i.e. Greater Poland Cancer Centre (Poznan, Poland), on condition that these materials are accepted for publication. The authors agree not to publish any data or figures presented in their work in any place or in any language without the prior written consent of the Publisher. |
| رقم الانضمام: |
edsbas.4ECD0CE8 |
| قاعدة البيانات: |
BASE |
