التفاصيل البيبلوغرافية
| العنوان: |
Iron deficiency anemia – new possibilities of iron supplementation in various clinical conditions |
| المؤلفون: |
Michalak, Sylwia Sulimiera |
| المصدر: |
Acta Haematologica Polonica; Vol 51, No 4 (2020); 212-219 |
| بيانات النشر: |
Via Medica |
| سنة النشر: |
2020 |
| المجموعة: |
Via Medica Journals |
| مصطلحات موضوعية: |
iron deficiency anemia, sucrosomial iron, iron maltol, iron citrate, iron nanocompounds |
| الوصف: |
Iron deficiency anemia (IDA) treatment is done to eliminate the causes of iron deficiency, iron supplementation, and rarely red blood cell transfusion. Divalent iron salts are the first line of oral treatment, but their use lead to frequent gastrointestinal adverse reactions. Iron is administered intravenously in the event of contraindications, intolerance, or inefficiency of oral therapy, but the parenteral route of drug delivery is not easily accepted by the patients. Intravenous preparations for single administration of a large dose of iron have a good therapy safety profile, but are more expensive than oral and are usually administered in a hospital setting. The availability of new iron compounds: sucrosomial iron, ferric citrate complexes, and ferric maltol widen the possibilities of IDA therapy and enable the better selection of iron preparations in various clinical situations. The innovative structure of sucrosomial iron leads to absorption in different ways (through endocytosis, the paracellular pathway, M cells of Peyer's patches), ensures high bioavailability, and good tolerance of therapy. Ferric citrate, in addition to iron supplementation, reduces phosphate levels, and is beneficial to chronic kidney disease. Ferric maltol is currently being studied for IDA treatment with various comorbidities. Some studies indicate that new iron formulas may be used where intravenous intake has been recommended so far. So, we can expect treatment with iron nanoparticles and drugs that affect the intestinal microflora in the future. The paper presents current knowledge about new iron preparations that are already available in everyday practice, but also those that are at various stages of pre-clinical and clinical studies. |
| نوع الوثيقة: |
other/unknown material |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://journals.viamedica.pl/acta_haematologica_polonica/article/view/75211Test |
| DOI: |
10.2478/ahp-2020-0037 |
| الإتاحة: |
https://doi.org/10.2478/ahp-2020-0037Test
https://journals.viamedica.pl/acta_haematologica_polonica/article/view/75211Test |
| حقوق: |
Completion of the online submission form electronically (the Author's Statement) is tantamount to automatic transfer of the copyright for publishing and distribution of the submitted material (in all current and future forms and fields of exploitation) to the Copyright Owner, i.e. Polish Society Haematology and Blood Transfusion, Institute of Haematology and Transfusion Medicine, on condition that these materials are accepted for publication. The authors agree not to publish any data or figures presented in their work in any place or in any language without the prior written consent of Via Medica. |
| رقم الانضمام: |
edsbas.40E137A1 |
| قاعدة البيانات: |
BASE |
