التفاصيل البيبلوغرافية
| العنوان: |
Serum sICAM, sVCAM and sE-selectin levels in colorectal cancer patients. |
| المؤلفون: |
Mantur, M, Snarska, J, Koper, O, Dziecioł, J, Płonski, A, Lemancewicz, D |
| المصدر: |
Folia Histochemica et Cytobiologica; Vol 47, No 4 (2009); 621-625 |
| بيانات النشر: |
Via Medica |
| سنة النشر: |
2010 |
| المجموعة: |
Via Medica Journals |
| الوصف: |
Colorectal cancer (CRC) is one of the most common cancers of the gastrointestinal tract and the fourth cause of cancers death in the world. Soluble adhesion molecules (CAMs) are thought to have an important role in host defense against carcinogenesis. They are biomarkers of inflammation and indicators of the immune response to tumors. The study included 40 CRC patients without remote metastases and 24 control subjects. Serum concentrations of sE-selectin, sICAM and sVCAM in patients with CRC were investigated by ELISA method. The level of the sCAMs decreased significantly after radical tumor resection. Preoperative serum concentrations of sICAM and sVCAM in CRC patients were significantly higher compared to the control group, whereas there were no differences regarding serum sE-selectin. Serum levels of sE-selectin, sICAM and sVCAM correlated significantly with each other. There was a significant correlation of serum levels of sICAM-1 and sVCAM-1, but not sE-selectin, with TNM stage and lymph node involvement. No significant relationship was found between serum concentrations of sICAM-1, sVCAM-1 and sE-selectin in CRC patients and patients' age or gender. Our findings suggest that an improved understanding of the mechanisms of membrane shedding of sICAM, sVCAM and sE-selectin is required to delineate their role in tumor progression. |
| نوع الوثيقة: |
other/unknown material |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
https://journals.viamedica.pl/folia_histochemica_cytobiologica/article/view/4308Test |
| DOI: |
10.2478/v10042-009-0077-0 |
| الإتاحة: |
https://doi.org/10.2478/v10042-009-0077-0Test
https://journals.viamedica.pl/folia_histochemica_cytobiologica/article/view/4308Test |
| حقوق: |
By sending the manuscript with figures and charts the author (authors) declares (declare) it has been neither published nor submitted to the Editorial Board of any other journal (not including the abstracts 400 words or less). Moreover, it is assumed that the copyright for publishing and distribution of the submitted material (in all known now and developed in the future forms and fields of exploitation) are automatically and free-of-charge transferred to the Polish Histochemical and Cytochemical Society, under condition that those materials are accepted for publication. The authors accept the fact, that the work will not be published anywhere and in any language without the prior written consent of the owner of the copyrights, i.e. the Polish Histochemical and Cytochemical Society. Independently to the formerly mentioned effects, author (authors) due to release form the responsibilities to the third parties, shall (should) attach the cover letter to the manuscript. The cover letter shall contain declaration of the author (authors) confirming formerly described facts and that all co-authors of the manuscript agree for the publication. Moreover the author (authors) confirm that they have acquaint themselves with the editorial policy in “Folia Histochemica et Cytobiologica” and they oblige to respect the policy. The reward for sending the manuscript is publication in the journal. The written permission from the previous Polish Histochemical and Cytochemical Society for the reprint should be enclosed to the materials (pictures, photos, figures, etc.) that have been printed previously. If the data presented in case reports, figures or in the text enable identification of the persons their written consent to the publication should be enclosed. Any potential conflict of interest will be dealt with by the local court specific to the Polish Histochemical and Cytochemical Society. Legal relations between the Polish Histochemical and Cytochemical Society and the author(s) are in accordance with Polish law and with international conventions binding to Poland. The legal bases to acquiring the copyright are article 921 section 3 sentence 3 of the civil code in connection with article 50 of the copyright law and related law as well as the international conventions binding to Poland. © Polish Histochemical and Cytochemical Society |
| رقم الانضمام: |
edsbas.6C84BE87 |
| قاعدة البيانات: |
BASE |
