رسالة جامعية
EGCG and Its Role in Prostate Cancer Angiogenesis
| العنوان: | EGCG and Its Role in Prostate Cancer Angiogenesis |
|---|---|
| المؤلفون: | Thomas, Rusha |
| المساهمون: | Porunelloor Mathew, Ming-Chi Wu, Dan Dimitrijevich |
| سنة النشر: | 2019 |
| المجموعة: | UNTHSC Scholarly Repository (University. of North Texas Health Science Center) |
| مصطلحات موضوعية: | Alternative and Complementary Medicine, Biochemistry, Cancer Biology, Cell Anatomy, Cell and Developmental Biology, Cell Biology, Cells, Chemicals and Drugs, Community Health and Preventive Medicine, Developmental Biology, Diseases, Life Sciences, Medical Cell Biology, Medical Nutrition, Medical Toxicology, Medicine and Health Sciences, Molecular Biology, Nutritional Epidemiology, Oncology, Organic Chemicals, Other Cell and Developmental Biology, Toxicology, EGCG, prostate cancer, angiogenesis, HIF-1, hypoxia inducible factor-1, upregulation, vascular endothelial growth factor, VEGF |
| الوصف: | Thomas, Rusha, EGCG and its role in prostate cancer angiogenesis. Master of Science (Biochemistry and Molecular Biology), May 2005, 47 pages, 14 illustrations, reference list, 44 titles. Hypoxia inducible factor-1 (HIF-1)-mediated upregulation of vascular endothelial growth factor (VEGF) has been implicated in angiogenesis associated with malignancies. HIF-1 consists of a constitutively expressed HIF-1β subunit, and a hypoxia-inducible HIF-1α subunit. Hypoxic induction of HIF-1α correlates with increased transcriptional activation of its downstream target genes, including VEGF. Epidemiologic and laboratory studies indicate that green tea has cancer preventive activity which has been attributed to its polyphenol components, the major one being epigallocatechin gallate (EGCG). This study investigated the effect of EGCG on normoxic VEGF expression in PC-3ML human prostate cancer cells. In contrast to previous studies where EGCG inhibited VEGF expression in breast and colon cancer cell lines, our results demonstrated that EGCG has the ability to upregulate HIF-1α transcription factor via inhibition of prolyl hydroxylation and subsequent von Hippel-Lindau protein interaction. HIF-1α upregulation by EGCG led to increased VEGF promoter activity and protein expression. |
| نوع الوثيقة: | thesis |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://hdl.handle.net/20.500.12503/27981Test |
| الإتاحة: | https://doi.org/20.500.12503/27981Test https://hdl.handle.net/20.500.12503/27981Test |
| رقم الانضمام: | edsbas.9355524B |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |