المؤلفون: Barba E., Kontou P.I., Michalopoulos I., Bagos P.G., Braliou G.G.

المصدر: Pharmacogenomics Journal ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122894409&doi=10.1038%2fs41397-021-00255-3&partnerID=40&md5=8cfc96beefee5e6bb72f5b0bdd58b20fTest

مصطلحات موضوعية: azathioprine, mercaptopurine, immunosuppressive agent, inorganic pyrophosphatase, ITPA protein, human, acute lymphoblastic leukemia, adverse drug reaction, age, alopecia, Article, bone marrow suppression, cancer patient, disease marker, DNA polymorphism, drug hypersensitivity, flu like syndrome, gene, genetic association, ITPA gene, leukopenia, liver toxicity, meta analysis, nausea and vomiting, neutropenia, pancreatitis, patient, pediatric patient, pharmacogenetics, prediction

الوصف: Azathioprine (AZA) and its metabolite, mercaptopurine (6-MP), are widely used immunosuppressant drugs. Polymorphisms in genes implicated in AZA/6-MP metabolism, reportedly, could account in part for their potential toxicity. In the present study we performed a systematic review and a meta-analysis, comprising 30 studies and 3582 individuals, to investigate the putative genetic association of two inosine triphosphatase (ITPA) polymorphisms with adverse effects in patients treated with AZA/6-MP. We found that rs1127354 is associated with neutropenia in general populations and in children (OR: 2.39, 95%CI: 1.97–2.90, and OR: 2.43, 95%CI: 2.12–2.79, respectively), and with all adverse effects tested herein in adult populations (OR: 2.12, 95%CI: 1.22–3.69). We also found that rs7270101 is associated with neutropenia and leucopenia in all-ages populations (OR: 2.93, 95%CI: 2.36–3.63, and OR: 2.82, 95%CI: 1.76–4.50, respectively) and with all adverse effects tested herein in children (OR: 1.74, 95%CI: 1.06–2.87). Stratification according to background disease, in combination with multiple comparisons corrections, verified neutropenia to be associated with both polymorphisms, in acute lymphoblastic leukemia (ALL) patients. These findings suggest that ITPA polymorphisms could be used as predictive biomarkers for adverse effects of thiopurine drugs to eliminate intolerance in ALL patients and clarify dosing in patients with different ITPA variants. © 2021, The Author(s), under exclusive licence to Springer Nature Limited.

العلاقة: http://hdl.handle.net/11615/71122Test

الإتاحة: https://doi.org/10.1038/s41397-021-00255-3Test
http://hdl.handle.net/11615/71122Test

المؤلفون: Deer R.R., Rock M.A., Vasilevsky N., Carmody L., Rando H., Anzalone A.J., Basson M.D., Bennett T.D., Bergquist T., Boudreau E.A., Bramante C.T., Byrd J.B., Callahan T.J., Chan L.E., Chu H., Chute C.G., Coleman B.D., Davis H.E., Gagnier J., Greene C.S., Hillegass W.B., Kavuluru R., Kimble W.D., Koraishy F.M., Köhler S., Liang C., Liu F., Liu H., Madhira V., Madlock-Brown C.R., Matentzoglu N., Mazzotti D.R., McMurry J.A., McNair D.S., Moffitt R.A., Monteith T.S., Parker A.M., Perry M.A., Pfaff E., Reese J.T., Saltz J., Schuff R.A., Solomonides A.E., Solway J., Spratt H., Stein G.S., Sule A.A., Topaloglu U., Vavougios G.D., Wang L., Haendel M.A., Robinson P.N.

المصدر: EBioMedicine ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119906989&doi=10.1016%2fj.ebiom.2021.103722&partnerID=40&md5=09072f9447a91d00af005bbef10ea793Test

مصطلحات موضوعية: ageusia, anosmia, anxiety, Article, cognitive defect, cohort analysis, coughing, depression, diarrhea, dyspnea, fatigue, fever, ground glass opacity, headache, heart palpitation, human, insomnia, intensive care unit, long COVID, memory disorder, myalgia, nausea, phenotype, pleura disease, posttraumatic stress disorder, respiratory tract infection, Severe acute respiratory syndrome coronavirus 2, sore throat, thorax pain, thorax radiography

الوصف: Background: Numerous publications describe the clinical manifestations of post-acute sequelae of SARS-CoV-2 (PASC or “long COVID”), but they are difficult to integrate because of heterogeneous methods and the lack of a standard for denoting the many phenotypic manifestations. Patient-led studies are of particular importance for understanding the natural history of COVID-19, but integration is hampered because they often use different terms to describe the same symptom or condition. This significant disparity in patient versus clinical characterization motivated the proposed ontological approach to specifying manifestations, which will improve capture and integration of future long COVID studies. Methods: The Human Phenotype Ontology (HPO) is a widely used standard for exchange and analysis of phenotypic abnormalities in human disease but has not yet been applied to the analysis of COVID-19. Findings: We identified 303 articles published before April 29, 2021, curated 59 relevant manuscripts that described clinical manifestations in 81 cohorts three weeks or more following acute COVID-19, and mapped 287 unique clinical findings to HPO terms. We present layperson synonyms and definitions that can be used to link patient self-report questionnaires to standard medical terminology. Long COVID clinical manifestations are not assessed consistently across studies, and most manifestations have been reported with a wide range of synonyms by different authors. Across at least 10 cohorts, authors reported 31 unique clinical features corresponding to HPO terms; the most commonly reported feature was Fatigue (median 45.1%) and the least commonly reported was Nausea (median 3.9%), but the reported percentages varied widely between studies. Interpretation: Translating long COVID manifestations into computable HPO terms will improve analysis, data capture, and classification of long COVID patients. If researchers, clinicians, and patients share a common language, then studies can be compared/pooled more effectively. Furthermore, ...

العلاقة: http://hdl.handle.net/11615/73159Test

الإتاحة: https://doi.org/10.1016/j.ebiom.2021.103722Test
http://hdl.handle.net/11615/73159Test

المؤلفون: Pleeging C.C.F., Coenye T., Mossialos D., Rooster H., Chrysostomou D., Wagener F.A.D.T.G., Cremers N.A.J.

المصدر: Antibiotics ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097306738&doi=10.3390%2fantibiotics9120866&partnerID=40&md5=d18ded75754cb6548659edb4d454cd08Test

مصطلحات موضوعية: amoxicillin plus clavulanic acid, ciprofloxacin, hemoglobin A1c, pseudomonic acid, abscess, antibiofilm activity, antibiotic resistance, antibiotic therapy, antimicrobial activity, apitherapy, Article, bacterial clearance, biofilm, body mass, case report, clinical article, debridement, decubitus, diabetic foot, diabetic ulcer, dizziness, enzyme linked immunosorbent assay, female, follow up, honey, insulin dependent diabetes mellitus, leg amputation, nausea, obesity, Pseudomonas aeruginosa

الوصف: Biofilms hinder wound healing. Medical-grade honey (MGH) is a promising therapy because of its broad-spectrum antimicrobial activity and the lack of risk for resistance. This study investigated the inhibitory and eradicative activity against multidrug-resistant Pseudomonas aeruginosa biofilms by different established MGH-based wound care formulations. Six different natural wound care products (Medihoney, Revamil, Mebo, Melladerm, L-Mesitran Ointment, and L-Mesitran Soft) were tested in vitro. Most of them contain MGH only, whereas some were supplemented. L-Mesitran Soft demonstrated the most potent antimicrobial activity (6.08-log inhibition and 3.18-log eradication). Other formulations ranged between 0.89-log and 4.80-log inhibition and 0.65-log and 1.66-log eradication. Therefore, the contribution of different ingredients of L-Mesitran Soft was investigated in more detail. The activity of the same batch of raw MGH (1.38-log inhibition and 2.35-log eradication), vitamins C and E (0.95-log inhibition and 0.94-log eradication), and all ingredients except MGH (1.69-log inhibition and 0.75-log eradication) clearly support a synergistic activity of components within the L-Mesitran Soft formulation. Several presented clinical cases illustrate its clinical antimicrobial efficacy against Pseudomonas aeruginosa biofilms. In conclusion, MGH is a potent treatment for Pseudomonas biofilms. L-Mesitran Soft has the strongest antimicrobial activity, which is likely due to the synergistic activity mediated by its supplements. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

العلاقة: http://hdl.handle.net/11615/78265Test

الإتاحة: https://doi.org/10.3390/antibiotics9120866Test
http://hdl.handle.net/11615/78265Test

المؤلفون: Grammatikopoulou M.G., Theodoridis X., Gkiouras K., Lampropoulou M., Petalidou A., Patelida M., Tsirou E., Papoutsakis C., Goulis D.G.

المصدر: Nutrition Reviews ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086135235&doi=10.1093%2fnutrit%2fnuz065&partnerID=40&md5=1ab4992107ff8aaf5cc2ac018e3f21e0Test

مصطلحات موضوعية: alcohol, caffeine, folic acid, methylmercury, nonnutritive sweetener, nutrition supplement, Article, bariatric surgery, body weight loss, caloric intake, craving, dietary fiber, dietary reference intake, food poisoning, gestational weight gain, healthy diet, heartburn, hemorrhoid, human, maternal hypertension, maternal nutrition, maternal obesity, multiple pregnancy, nausea, nutritional deficiency, obesity management, practice guideline, pregnancy, stakeholder engagement, systematic review

الوصف: Context: Ensuring a healthy pregnancy and achieving optimal gestational weight gain (GWG) are important for maternal and child health. Nevertheless, the nutritional advice provided during pregnancy is often conflicting, suggesting limited adherence to clinical practice guidelines (CPGs). Objective: The aim of this review was to identify all CPGs on maternal nutrition and GWG and to critically appraise their methodological quality. Data Sources: The MEDLINE/PubMed, Cochrane, Guidelines International Network, and BMJ Best Practice databases, along with gray literature, were searched from inception until February 2019 for CPGs and consensus, position, and practice papers. Study Selection: Clinical practice guidelines published in English and containing advice on maternal nutrition or GWG were eligible. Data Extraction: Two authors independently extracted data on items pertaining to maternal nutrition or GWG, and CPGs were appraised using the AGREE II instrument. Results: Twenty-two CPGs were included. All scored adequately in the "scope"domain, but most were considered inadequate with regard to stakeholder involvement, rigor of development, applicability, and editorial independence. Many CPGs lacked patient or dietician involvement, and more than half did not disclose funding sources or conflicts of interest. Guidance on GWG was based mostly on Institute of Medicine thresholds, while nutrition recommendations appeared scattered and heterogeneous. Conclusion: Despite the importance of maternal nutrition and the plethora of advising bodies publishing relevant guidance, there is room for substantial improvement in terms of development standards and content of nutritional recommendations. Systematic review registration: PROSPERO registration number CRD42019120898. © 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the International Life Sciences Institute.

العلاقة: http://hdl.handle.net/11615/72731Test

الإتاحة: https://doi.org/10.1093/nutrit/nuz065Test
http://hdl.handle.net/11615/72731Test

المؤلفون: Giannis D., Moris D., Shaw B.I., Vernadakis S.

المصدر: Molecular and Clinical Oncology ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087127469&doi=10.3892%2fmco.2020.2034&partnerID=40&md5=634bb16005e33992ac2730baf0528ea6Test

مصطلحات موضوعية: cyclosporine, mycophenolate mofetil, steroid, adult, Article, case report, chondrosarcoma, chronic graft rejection, clinical article, computer assisted tomography, diabetic nephropathy, dialysis, end stage renal disease, epigastric pain, female, follow up, histopathology, human, immunosuppressive treatment, kidney transplantation, laparotomy, nausea, nuclear magnetic resonance imaging, postoperative care, thoracic chondrosarcoma, Spandidos Publications

الوصف: Primary thoracic bone tumors are relatively rare. The most common type is chondrosarcoma, accounting for up to 48% of all cases. Patients with primary thoracic bone tumors commonly present with atypical thoracic pain or a solitary palpable chest mass, which gradually develops over months to years. The bones most often affected are the ribs, scapula, costochondral junctions and the sternum. The present study presents a case of a 79 year old previous transplant recipient with a large intra-abdominally expanding chondrosarcoma originating from the left lower thoracic cage and associated vague abdomdinal symptoms. Early recognition and awareness of atypical presentations of this disease are important in to appropriately guide diagnostic evaluation and therapeutic procedures. © 2020, Spandidos Publications. All rights reserved.

العلاقة: http://hdl.handle.net/11615/72333Test

الإتاحة: https://doi.org/10.3892/mco.2020.2034Test
http://hdl.handle.net/11615/72333Test

المؤلفون: Zoulamoglou M., Flessas I., Zarokosta M., Piperos T., Kalles V., Tsiaousis I., Kaklamanos I., Sgantzos M., Mariolis-Sapsakos T.

المصدر: International Journal of Surgery Case Reports ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-84981314721&doi=10.1016%2fj.ijscr.2016.07.046&partnerID=40&md5=afbe6c1b77fcb9efc3b26a10203a80e4Test

مصطلحات موضوعية: abdominal distension, abdominal pain, abdominal scintiscanning, adult, Article, case report, cesarean section, colic, computer assisted tomography, congenital malformation, female, human, laparoscopy, nausea, peritoneal disease, peritoneal encapsulation, peritoneum, priority journal, small intestine disease, small intestine obstruction, Elsevier Ltd

الوصف: Introduction Peritoneal Encapsulation (PE) is a scarce congenital malformation, characterized by a supplementary peritoneal membrane that covers all or a part of the small intestine. Presentation of case PE was unexpectantly discovered in a young woman during laparotomy for bowel obstruction. There were no specific pre-operative indications of this malformation. The operation was uneventful. Discussion PE is a very rare congenital anatomical anomaly that is difficultly identified pre-operatively. PE is mainly asymptomatic, but in some cases, like in the presented one, PE presents with small bowel obstruction. Surgeons should be aware of this malformation and suspect it when encountering a patient with small bowel obstruction without other etiological factors. Conclusion Knowledge of this peculiar congenital anomaly is pivotal, so that accurate diagnosis and appropriate management of it are direct and efficient. © 2016 The Authors

العلاقة: http://hdl.handle.net/11615/81036Test

الإتاحة: https://doi.org/10.1016/j.ijscr.2016.07.046Test
http://hdl.handle.net/11615/81036Test

المؤلفون: Garcia-Borreguero D., Silber M.H., Winkelman J.W., Högl B., Bainbridge J., Buchfuhrer M., Hadjigeorgiou G., Inoue Y., Manconi M., Oertel W., Ondo W., Winkelmann J., Allen R.P.

المصدر: Sleep Medicine ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-84963549037&doi=10.1016%2fj.sleep.2016.01.017&partnerID=40&md5=5e953babfd6991a350085fccebba043dTest

مصطلحات موضوعية: gabapentin, gabapentin enacarbil, iron, methadone, naltrexone, oxycodone, pramipexole, pregabalin, ropinirole, rotigotine, dopamine receptor stimulating agent, Article, backache, constipation, diarrhea, dizziness, drug efficacy, drug safety, drug withdrawal, evidence based medicine, fatigue, headache, human, influenza, iron therapy, nausea, practice guideline, prevalence, primary health care, priority journal

الوصف: A Task Force was established by the International Restless Legs Syndrome Study Group (IRLSSG) in conjunction with the European Restless Legs Syndrome Study Group (EURLSSG) and the RLS Foundation (RLS-F) to develop evidence-based and consensus-based recommendations for the prevention and treatment of long-term pharmacologic treatment of dopaminergic-induced augmentation in restless legs syndrome/Willis-Ekbom disease (RLS/WED).The Task Force made the following prevention and treatment recommendations:. As a means to prevent augmentation, medications such as α2δ ligands may be considered for initial RLS/WED treatment; these drugs are effective and have little risk of augmentation. Alternatively, if dopaminergic drugs are elected as initial treatment, then the daily dose should be as low as possible and not exceed that recommended for RLS/WED treatment. However, the physician should be aware that even low dose dopaminergics can cause augmentation. Patients with low iron stores should be given appropriate iron supplementation. Daily treatment by either medication should start only when symptoms have a significant impact on quality of life in terms of frequency and severity; intermittent treatment might be considered in intermediate cases.Treatment of existing augmentation should be initiated, where possible, with the elimination/correction of extrinsic exacerbating factors (iron levels, antidepressants, antihistamines, etc.). In cases of mild augmentation, dopamine agonist therapy can be continued by dividing or advancing the dose, or increasing the dose if there are breakthrough night-time symptoms. Alternatively, the patient can be switched to an α2δ ligand or rotigotine. For severe augmentation the patient can be switched either to an α2δ ligand or rotigotine, noting that rotigotine may also produce augmentation at higher doses with long-term use. In more severe cases of augmentation an opioid may be considered, bypassing α2δ ligands and rotigotine. © 2016 The Authors.

العلاقة: http://hdl.handle.net/11615/71955Test

الإتاحة: https://doi.org/10.1016/j.sleep.2016.01.017Test
http://hdl.handle.net/11615/71955Test

المؤلفون: Petsiti A., Tassoudis V., Vretzakis G., Zacharoulis D., Tepetes K., Ganeli G., Karanikolas M.

المصدر: Anesthesiology Research and Practice ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-84934920490&doi=10.1155%2f2015%2f829151&partnerID=40&md5=413da6bc027c326888493c1d42574e3cTest

مصطلحات موضوعية: abdominal surgery, adult, age, anesthesia level, Article, bispectral index, cardiovascular disease, comorbidity, deep hypnotic time, disease course, elective surgery, female, gastrointestinal symptom, hospitalization, human, hypotension, lung complication, major clinical study, major surgery, male, middle aged, morbidity, nausea, observational study, operation duration, outcome assessment, perioperative period, postoperative complication, priority journal, prospective study

الوصف: Introduction. The prognostic value of age, physical status, and duration of surgery on perioperative course has been extensively studied. However, the impact of deep hypnotic time (time when Bispectral Index values are less than 40) has not been well evaluated. Methods. We designed an observational study to clarify the relative influence of deep hypnotic time (DHT) on outcome. Eligible participants were mentally stable patients over 18 years old scheduled for elective major abdominal surgery. In total, 248 patients enrolled. Data were analyzed using Fisher's exact test and multiple logistic regression. Results. Five variables (DHT, hypotension, age, comorbidity, and duration of surgery) showed statistically significant association with complications, when examined independently. However, when all variables were examined together in a multiple logistic regression model, age and comorbidity were no longer associated with outcome. DHT, hypotension, and duration of surgery were significant predictors of "complications," and "hypotension" was a significant predictor of prolonged hospital stay (P < 0.001). Conclusion. Deep hypnotic time emerged as a new factor associated with outcome, and its impact compared to other factors such as age, surgery duration, hypotension, and comorbidity is redefined. Monitoring and managing depth of anesthesia during surgery are important and should be part of careful operation planning. © 2015 Argyro Petsiti et al.

العلاقة: http://hdl.handle.net/11615/78192Test

الإتاحة: https://doi.org/10.1155/2015/829151Test
http://hdl.handle.net/11615/78192Test

المؤلفون: Schwartzberg, L. S., Jacobs, P., Matsouka, P., Azevedo, W., Pinto, A.

المصدر: ://WOS:000306147100006

مصطلحات موضوعية: Chemotherapy-induced nausea and vomiting, Antiemetics, 5HT3 receptor, antagonists, Palonosetron, Stem cell transplantation, MODERATELY EMETOGENIC CHEMOTHERAPY, STEM-CELL TRANSPLANTATION, HIGH-DOSE, CHEMOTHERAPY, PLACEBO-CONTROLLED TRIAL, ACUTE MYELOID-LEUKEMIA, DOUBLE-BLIND, PHASE-III, RANDOMIZED-TRIAL, DELAYED NAUSEA, IN-VITRO, Oncology, Hematology

الوصف: Compared with solid tumor patients, those with hematological malignancies are at particular risk of chemotherapy-induced nausea and vomiting (CINV) because of their young age, exposure to highly-emetogenic induction, consolidation and salvage regimens, the high-dose conditioning regimens used before stem cell transplantation (SCT), and the heavy psychological burden of such treatments. In the absence of prophylaxis, around 75% of patients undergoing SCT experience delayed CINV. With first-generation 5-HT3 receptor antagonists, only about 20% are completely protected from nausea and vomiting, and this frequent and debilitating adverse event has not been fully addressed. In contrast to solid tumors, there are no internationally agreed guidelines for the prevention and treatment of CINV in hematological malignancies. Work on a consensus is urgently required. The second-generation 5-HT3 antagonist palonosetron is highly effective in preventing CINV in patients with solid tumors. The extended half-life of this agent and its mechanisms of action including allosteric binding, positive cooperativity and 5-HT3 receptor internalization, may make it particularly effective in controlling delayed CINV. Although controlled comparisons against first-generation 5HT(3) agents have not yet been conducted in the setting of SCT, available evidence suggests that palonosetron may prove beneficial in preventing CINV in high risk patients with hematological malignancies. (C) 2012 Published by Elsevier Ireland Ltd.

العلاقة: http://hdl.handle.net/11615/32938Test

الإتاحة: https://doi.org/10.1016/j.critrevonc.2011.09.005Test
http://hdl.handle.net/11615/32938Test

المؤلفون: Tiaka, E. K., Papanas, N., Manolakis, A. C., Georgiadis, G. S.

المصدر: http://www.scopus.com/inward/record.url?eid=2-s2.0-84861708902&partnerID=40&md5=4aeb847df2bd8f7bfddb1e7d11632ee0Test.

مصطلحات موضوعية: diabetic foot, epidermal growth factor (EGF), growth factors, wound healing, actovegin, recombinant epidermal growth factor, anemia, article, chill, cost effectiveness analysis, diabetes mellitus, drug bioavailability, drug efficacy, epithelium cell, evidence based practice, fever, fibroblast, human, injection site pain, nausea, priority journal, rash, sepsis, skin burning sensation, skin irritation, tremor, vomiting, Adult, Aged, Drug Administration Routes

الوصف: Management of diabetic foot ulcers remains a rather challenging task. Epidermal growth factor (EGF) plays a central role in wound healing. It acts on epithelial cells and fibroblasts promoting restoration of damaged epithelium. However, its bioavailability is impaired in chronic diabetic foot ulcers. Current evidence suggests that application of human recombinant EGF in addition to standard treatment is able to achieve both partial and complete healing and to prevent foot amputations. Its efficacy has been tested at various concentrations and by various administration routes (topical application and intralesional injection). Intralesional injection has better availability on the deep wound layers, but pain at the injection site is a common complaint. Generally, adverse events have been minor to mild. Finally, numerous issues need to be further clarified before widespread use of EGF becomes possible in everyday practice. Such issues include optimal dosage and administration route, characteristics of the ulcers most likely to heal (severity and ischemic/neuropathic or both), and cost-effectiveness. © The Author(s) 2012.

العلاقة: http://hdl.handle.net/11615/33661Test

الإتاحة: https://doi.org/10.1177/1531003512442093Test
http://hdl.handle.net/11615/33661Test