دورية أكاديمية
Six months exposure to a real life mixture of 13 chemicals' below individual NOAELs induced non monotonic sex-dependent biochemical and redox status changes in rats
| العنوان: | Six months exposure to a real life mixture of 13 chemicals' below individual NOAELs induced non monotonic sex-dependent biochemical and redox status changes in rats |
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| المؤلفون: | Docea A.O., Gofita E., Goumenou M., Calina D., Rogoveanu O., Varut M., Olaru C., Kerasioti E., Fountoucidou P., Taitzoglou I., Zlatian O., Rakitskii V.N., Hernandez A.F., Kouretas D., Tsatsakis A. |
| المصدر: | Food and Chemical Toxicology ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046865183&doi=10.1016%2fj.fct.2018.03.052&partnerID=40&md5=bb89faa6b56fdf7f641d83f4c5ef6239Test |
| سنة النشر: | 2018 |
| المجموعة: | University of Thessaly Institutional Repository / Ιδρυματικό Αποθετήριο Πανεπιστημίου Θεσσαλίας |
| مصطلحات موضوعية: | 4,4' isopropylidenediphenol, alanine aminotransferase, alkaline phosphatase, aspartame, benzoic acid, bilirubin, butyl paraben, carbaril, catalase, cholesterol, creatine kinase, creatinine, dimethoate, edetate calcium disodium, ethyl paraben, glucose, glutathione, glyphosate, gum arabic, methomyl, parathion methyl, triadimefon, alanine aminotransferase blood level, animal experiment, Article, aspartate aminotransferase blood level, bilirubin blood level, body weight gain, cholesterol blood level, controlled study |
| الوصف: | This study assessed the potential adverse health effects of long-term low-dose exposure to chemical mixtures simulating complex real-life human exposures. Four groups of Sprague Dawley rats were administered mixtures containing carbaryl, dimethoate, glyphosate, methomyl, methyl parathion, triadimefon, aspartame, sodium benzoate, calcium disodium ethylene diamine tetra-acetate, ethylparaben, butylparaben, bisphenol A, and acacia gum at doses of 0, 0.25, 1 or 5 times the respective Toxicological Reference Values (TRV): acceptable daily intake (ADI) or tolerable daily intake (TDI) in a 24 weeks toxicity study. Body weight gain, feed and water consumption were evaluated weekly. At 24 weeks blood was collected and biochemistry parameters and redox status markers were assessed. Adverse effects were observed on body weight gain and in hepatotoxic parameters such as the total bilirubin, alanine aminotransferase (ALT) and alkaline phosphatase (ALP), especially in low dose and affecting mainly male rats. The low dose group showed increased catalase activity both in females and males, whereas the high dose group exhibited decreased protein carbonyl and total antioxidant capacity (TAC) levels in both sex groups. Non-monotonic effects and adaptive responses on liver function tests and redox status, leading to non-linear dose-responses curves, are probably produced by modulation of different mechanisms. © 2018 Elsevier Ltd |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 02786915 |
| العلاقة: | http://hdl.handle.net/11615/73394Test |
| DOI: | 10.1016/j.fct.2018.03.052 |
| الإتاحة: | https://doi.org/10.1016/j.fct.2018.03.052Test http://hdl.handle.net/11615/73394Test |
| رقم الانضمام: | edsbas.F564CCA0 |
| قاعدة البيانات: | BASE |
| تدمد: | 02786915 |
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| DOI: | 10.1016/j.fct.2018.03.052 |