التفاصيل البيبلوغرافية
| العنوان: |
Effect of single dose irradiation on human glioblastoma spheroids in vitro |
| المؤلفون: |
Fehlauer, F., Stalpers, L. J. A., Panayiotides, J., Kaaijk, P., González Gonźalez, D., Leenstra, S., Van Der Valk, P., Sminia, P. |
| المصدر: |
Oncology Reports ; http://www.scopus.com/inward/record.url?eid=2-s2.0-3242755230&partnerID=40&md5=edcf33392066267b3cd2c9bc07f209fbTest |
| سنة النشر: |
2004 |
| المجموعة: |
University of Thessaly Institutional Repository / Ιδρυματικό Αποθετήριο Πανεπιστημίου Θεσσαλίας |
| مصطلحات موضوعية: |
Glioma, Histology, Irradiation, Radiosurgery, Spheroids, protein p53, transforming growth factor beta, tumor marker, vasculotropin A, article, brain tumor, glioblastoma, human, methodology, mortality, organ culture technique, pathology, prediction and forecasting, radiotherapy, survival, Brain Neoplasms, Humans, Organ Culture Techniques, Predictive Value of Tests, Survival Analysis, Tumor Markers, Biological, Tumor Suppressor Protein p53, Vascular Endothelial Growth Factor A |
| الوصف: |
Investigation of the predictive value of a radiosurgery-relevant treatment of glioblastoma spheroids. Organotypic multicellular spheroids were cultured and irradiated (20 Gy). Morphology, apoptosis and immunohistochemical expression of p53, p21, MIB-1, TGF-β and VEGF were examined 4 h, 24 h, 7 days, and 14 days following treatment. Cell proliferation decreased, while apoptosis was increased. No morphological damage was observed. p53 expression was significantly increased after 4 h. TGF-β and VEGF expression were only slightly altered. Particularly early changes in proliferation and apoptosis can be observed in spheroids. Individual response differences suggest spheroids of human gliomas to be useful for monitoring radiosurgery effects. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| تدمد: |
1021335X |
| العلاقة: |
http://hdl.handle.net/11615/27434Test |
| الإتاحة: |
http://hdl.handle.net/11615/27434Test |
| رقم الانضمام: |
edsbas.4D462A88 |
| قاعدة البيانات: |
BASE |
