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1دورية أكاديمية
المؤلفون: Vavougios G., Kerenidi T., Tsilioni I., Zarogiannis S.G., Gourgoulianis K.I.
المصدر: Redox Report ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955299548&doi=10.1179%2f1351000215Y.0000000023&partnerID=40&md5=0704c771f4f24d075776f8dec1d4c10dTest
مصطلحات موضوعية: 8 isoprostane, copper zinc superoxide dismutase, copper zinc superoxide dismutase 1, DJ 1 protein, lactate dehydrogenase, unclassified drug, 8-epi-prostaglandin F2alpha, antioxidant, oncoprotein, PARK7 protein, human, prostaglandin F2 alpha, protein deglycase DJ-1, signal peptide, superoxide dismutase, age, aged, analytical parameters, Article, clinical article, comparative study, controlled study, female, geriatric patient, leukocyte count, lung cancer, male, malignant pleura effusion, non small cell lung cancer, oxidative stress
الوصف: Objectives: DJ-1 is a multifunctional protein implicated in redox dependent cell fate decisions. The aim of ourstudy was to determine the pleural fluid (PF) levels of DJ-1 in malignant pleural effusions (MPEs) secondary tolung cancer. Additionally, we opted to assess potential correlations of DJ-1 PF levels with the PF levels ofsuperoxide dismutase-1 (SOD1) and 8-isoprostane that are known antioxidant enzymes and have beenpreviously reported in MPEs. Methods: Forty lung cancer patients with cytological proof of MPE were enrolled in this study. The PF levels ofDJ-1, SOD1, and 8-isoprostane were measured by means of enzyme-linked immunosorbent assay.Results: The median PF levels of DJ-1 were 826 ng/mL (interquartile range, IQR: 482–1010 ng/mL). DJ-1 PFlevels significantly correlated with PF Cu/Zn-SOD1 and PF 8-isoprostane levels (Spearman’s rho, r;r = −0476, P = 0002 and r = −0264, P = 0033, respectively), PF lactate dehydrogenase (r = −0497,P = 0001) and total PF cell counts (r = −0325, P = 0041). Finally, in patients aged over 65 the PF DJ-1levels were significantly higher than patients aged less than 65 (875 ng/mL vs. 607 ng/mL, respectively,P = 0037).Discussion: To our knowledge, this is the first report to determine DJ-1’s levels in MPEs due to lung cancer.The negative correlations between DJ-1, SOD1, and 8-isorpostane warrant further investigation regarding thealtered redox regulation associated with MPEs. © W. S. Maney & Son Ltd 2015.
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2دورية أكاديمية
المؤلفون: Tsitsimpikou, C., Kioukia-Fougia, N., Tsarouhas, K., Stamatopoulos, P., Rentoukas, E., Koudounakos, A., Papalexis, P., Liesivuori, J., Jamurtas, A.
المصدر: ://WOS:000329000800003
مصطلحات موضوعية: Creatinine phosphokinase, Lactate dehydrogenase, Lycopene, Anti-oxidant, Anaerobic training, C-REACTIVE PROTEIN, OXIDATIVE STRESS, CARDIOVASCULAR-DISEASE, ENDOTHELIAL FUNCTION, NATRIURETIC PEPTIDE, PHYSICAL-EXERCISE, HEALTHY-SUBJECTS, VITAMIN-C, PLASMA, Food Science & Technology, Toxicology
الوصف: Creatinine phosphokinase (CPK) and lactate dehydrogenase (LDH) are important biological markers of various myocardial disorders and exercise-induced muscle damage. Lycopene, on the other side, is a natural anti-oxidant with protective action against cardiovascular risk. Fifteen anaerobically trained athletes with elevated LDH and CPK baseline levels were enrolled in this study after undergoing thorough biochemical and cardiovascular evaluation with echocardiocraphy. In nine athletes tomato juice, a lycopene plain juice, was administered during and after exercise, replacing the carbohydrate supplementation beverages commonly used during training for over a 2-month period. Tomato juice administration significantly reduced LDH and CPK levels, which returned back to almost normal levels. At the same time homocysteine and C-reactive protein were also attenuated. No changes were observed in the control group, where the usual carbohydrate supplementation had been followed. (C) 2012 Elsevier Ltd. All rights reserved.
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