دورية أكاديمية
Pleural effusion levels of dj-1 are increased in elderly lung cancer patients with malignant pleural effusions
| العنوان: | Pleural effusion levels of dj-1 are increased in elderly lung cancer patients with malignant pleural effusions |
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| المؤلفون: | Vavougios G., Kerenidi T., Tsilioni I., Zarogiannis S.G., Gourgoulianis K.I. |
| المصدر: | Redox Report ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955299548&doi=10.1179%2f1351000215Y.0000000023&partnerID=40&md5=0704c771f4f24d075776f8dec1d4c10dTest |
| سنة النشر: | 2015 |
| المجموعة: | University of Thessaly Institutional Repository / Ιδρυματικό Αποθετήριο Πανεπιστημίου Θεσσαλίας |
| مصطلحات موضوعية: | 8 isoprostane, copper zinc superoxide dismutase, copper zinc superoxide dismutase 1, DJ 1 protein, lactate dehydrogenase, unclassified drug, 8-epi-prostaglandin F2alpha, antioxidant, oncoprotein, PARK7 protein, human, prostaglandin F2 alpha, protein deglycase DJ-1, signal peptide, superoxide dismutase, age, aged, analytical parameters, Article, clinical article, comparative study, controlled study, female, geriatric patient, leukocyte count, lung cancer, male, malignant pleura effusion, non small cell lung cancer, oxidative stress |
| الوصف: | Objectives: DJ-1 is a multifunctional protein implicated in redox dependent cell fate decisions. The aim of ourstudy was to determine the pleural fluid (PF) levels of DJ-1 in malignant pleural effusions (MPEs) secondary tolung cancer. Additionally, we opted to assess potential correlations of DJ-1 PF levels with the PF levels ofsuperoxide dismutase-1 (SOD1) and 8-isoprostane that are known antioxidant enzymes and have beenpreviously reported in MPEs. Methods: Forty lung cancer patients with cytological proof of MPE were enrolled in this study. The PF levels ofDJ-1, SOD1, and 8-isoprostane were measured by means of enzyme-linked immunosorbent assay.Results: The median PF levels of DJ-1 were 826 ng/mL (interquartile range, IQR: 482–1010 ng/mL). DJ-1 PFlevels significantly correlated with PF Cu/Zn-SOD1 and PF 8-isoprostane levels (Spearman’s rho, r;r = −0476, P = 0002 and r = −0264, P = 0033, respectively), PF lactate dehydrogenase (r = −0497,P = 0001) and total PF cell counts (r = −0325, P = 0041). Finally, in patients aged over 65 the PF DJ-1levels were significantly higher than patients aged less than 65 (875 ng/mL vs. 607 ng/mL, respectively,P = 0037).Discussion: To our knowledge, this is the first report to determine DJ-1’s levels in MPEs due to lung cancer.The negative correlations between DJ-1, SOD1, and 8-isorpostane warrant further investigation regarding thealtered redox regulation associated with MPEs. © W. S. Maney & Son Ltd 2015. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 13510002 |
| العلاقة: | http://hdl.handle.net/11615/80517Test |
| DOI: | 10.1179/1351000215Y.0000000023 |
| الإتاحة: | https://doi.org/10.1179/1351000215Y.0000000023Test http://hdl.handle.net/11615/80517Test |
| رقم الانضمام: | edsbas.30DC539F |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 13510002 |
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| DOI: | 10.1179/1351000215Y.0000000023 |