التفاصيل البيبلوغرافية
| العنوان: |
Syndecan-1, epithelial-mesenchymal transition markers (E-cadherin/β-catenin) and neoangiogenesis-related proteins (PCAM-1 and Endoglin) in colorectal cancer |
| المؤلفون: |
Mitselou A., Galani V., Skoufi U., Arvanitis D.L., Lampri E., Ioachim E. |
| المصدر: |
Anticancer Research ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85012273384&partnerID=40&md5=c018305ac05c4b8d7638a13148d11206Test |
| سنة النشر: |
2016 |
| المجموعة: |
University of Thessaly Institutional Repository / Ιδρυματικό Αποθετήριο Πανεπιστημίου Θεσσαλίας |
| مصطلحات موضوعية: |
beta catenin, CD31 antigen, cell marker, endoglin, formaldehyde, paraffin, syndecan 1, tumor marker, uvomorulin, cadherin, CDH1 protein, human, CTNNB1 protein, ENG protein, SDC1 protein, tumor protein, adult, aged, Article, cancer growth, cancer patient, cancer prognosis, cancer recurrence, cancer risk, cancer survival, carcinogenesis, clinical feature, colon mucosa, colorectal cancer, epithelial mesenchymal transition |
| الوصف: |
The Syndecan-1 protein plays a crucial role in cell proliferation, cell adhesion, cell migration and angiogenesis and, at the same time, its co-expression with E-cadherin is regulated during epithelial-mesenchymal transition (EMT). In colorectal cancer (CRC), the expression of syndecan-1, E-cadherin/β-catenin complex is frequently disturbed. Angiogenesis is critical for the growth and metastatic spread of tumors. In the present study, we focused on the expression of these biological molecules and their prognostic significance in human CRC. Formalin-fixed paraffin-embedded surgical specimens from 69 patients with CRC were immunostained for syndecan-1, E-cadherin, β-catenin, endoglin (CD105) and CD31 (platelet cell adhesion molecule (PCAM-1)). A significant association was found between syndecan-1 with E-cadherin (p<0.0001), as well with β-catenin (p<0.0001). High β-catenin expression appeared to reduce the risk of poor outcome. Endoglin microvascular density (MVD) count was correlated significantly with Dukes' stage (p<0.0001), vessel invasion (p<0.0001), lymph node metastasis (p=0.039), liver metastasis (p<0.0001), recurrence of disease (p=0.010) and poor survival rate (p<0.0001). Endoglin tumor epithelial cell expression was associated with E-cadherin, β-catenin and syndecan-1 (p=0.001, p=0.068 and p=0.005, respectively). In conclusion, changes in the pattern of expression of syndecan-1, EMT markers, E-cadherin/β-catenin, in association with endoglin (CD105), may be involved in tumor progression and prognosis of CRC patients. Further studies are needed to clarify the interaction between these proteins and tumor initiation and progression. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
02507005 |
| العلاقة: |
http://hdl.handle.net/11615/76684Test |
| الإتاحة: |
http://hdl.handle.net/11615/76684Test |
| رقم الانضمام: |
edsbas.DD6ACF38 |
| قاعدة البيانات: |
BASE |
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