دورية أكاديمية
The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma
| العنوان: | The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma |
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| المؤلفون: | Wagener, R., Seufert, J., Raimondi, F., Bens, S., Kleinheinz, K., Nagel, I., Altmueller, J., Thiele, H., Huebschmann, D., Kohler, Christian, Nürnberg, P., Au-Yeung, R., Burkhardt, B., Horn, H., Leoncini, L., Jaffe, E. S., Ott, G., Rymkiewicz, G., Schlesner, M., Russell, R. B., Klapper, W., Siebert, R. |
| بيانات النشر: | AMER SOC HEMATOLOGY |
| سنة النشر: | 2018 |
| المجموعة: | University of Regensburg Publication Server |
| مصطلحات موضوعية: | 610 Medizin, ddc:610 |
| الوصف: | The new recently described provisional lymphoma category Burkitt-like lymphoma with 11q aberration comprises cases similar to Burkitt lymphoma (BL) on morphological, immunophenotypic and gene-expression levels but lacking the IG-MYC translocation. They are characterized by a peculiar imbalance pattern on chromosome 11, but the landscape of mutations is not yet described. Thus, we investigated 15 MYC-negative Burkitt-like lymphoma with 11q aberration (mnBLL, 11q,) cases by copy-number analysis and whole-exome sequencing. We refined the regions of 11q imbalance and identified the INO80 complex-associated gene NFRKB as a positional candidate in 11q24.3. Next to recurrent gains in 12q13.11-q24.32 and 7q34-qter as well as losses in 13q32.3-q34, we identified 47 genes recurrently affected by protein-changing mutations (each >= 3 of 15 cases). Strikingly, we did not detect recurrent mutations in genes of the ID3-TCF3 axis or the SWI/SNF complex that are frequently altered in BL, or in genes frequently mutated in germinal center-derived B-cell lymphomas like KMT2D or CREBBP. An exception is GNA13, which was mutated in 7 of 15 cases. We conclude that the genomic landscape of mnBLL, 11q, differs from that of BL both at the chromosomal and mutational levels. Our findings implicate that mnBLL, 11q, is a lymphoma category distinct from BL at the molecular level. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | Wagener, R., Seufert, J., Raimondi, F., Bens, S., Kleinheinz, K., Nagel, I., Altmueller, J., Thiele, H., Huebschmann, D., Kohler, Christian, Nürnberg, P., Au-Yeung, R., Burkhardt, B., Horn, H., Leoncini, L., Jaffe, E. S., Ott, G., Rymkiewicz, G. , Schlesner, M. , Russell, R. B. , Klapper, W. und Siebert, R. (2018) The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma. Blood. |
| الإتاحة: | https://epub.uni-regensburg.de/38169Test/ http://www.bloodjournal.org/content/early/2018/12/19/blood-2018-07-864025Test |
| رقم الانضمام: | edsbas.69A2D0D2 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |