دورية أكاديمية
Adaptive immune responses against parvovirus B19 in patients with myocardial disease.
| العنوان: | Adaptive immune responses against parvovirus B19 in patients with myocardial disease. |
|---|---|
| المؤلفون: | Lindner, Juha, Noutsias, Michel, Lassner, Dirk, Wenzel, Jürgen, Schultheiss, Heinz-Peter, Kuehl, Uwe, Modrow, Susanne |
| سنة النشر: | 2009 |
| المجموعة: | University of Regensburg Publication Server |
| مصطلحات موضوعية: | 610 Medizin, ddc:610 |
| الوصف: | BACKGROUND: Parvovirus B19 (B19V)-DNA is frequently detected in endomyocardial biopsies (EMBs) from patients with acute myocarditis (AMC) and dilated cardiomyopathy (DCM), but also in various healthy tissues. The clinical relevance of this DNA-persistence is unclear. OBJECTIVES: To investigate potential pathogenic influences of B19V-DNA in EMBs, we analyzed B19V-specific adaptive immune responses in AMC/DCM patients and healthy controls. STUDY DESIGN: 15 AMC/DCM patients with detectable B19V-DNA in EMBs and 51 controls were analyzed for signs of acute B19V-infections and virus-specific immune responses by PCR, ELISA, Western line, and ELISpot-assays. RESULTS: Productive B19V-infection was determined in three patients. Slightly lower levels of B19V-specific T-cells were observed in patients as compared to the controls, no differences were observed in virus-specific serology. Viral DNA-load in EMBs could not be correlated to the number of B19V-specific T-cells. No differences in T-cell response, viremia and/or serological markers indicative for viral pathogenesis were observed in patients with inflammatory cardiomyopathy. CONCLUSIONS: Discrepancies in B19V-specific adaptive immunity were not observed in AMC/DCM patients as compared to controls. The data indicate that the exclusive detection of B19V-DNA in EMBs is not sufficient to associate B19V with AMC/DCM but should be complemented with additional virological and immunological parameters in further studies. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://epub.uni-regensburg.de/9992/1/2009_Lindner_ParvoB19-JCV.pdfTest; Lindner, Juha, Noutsias, Michel, Lassner, Dirk, Wenzel, Jürgen, Schultheiss, Heinz-Peter, Kuehl, Uwe und Modrow, Susanne (2009) Adaptive immune responses against parvovirus B19 in patients with myocardial disease. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 44 (1), S. 27-32. |
| الإتاحة: | https://epub.uni-regensburg.de/9992Test/ https://epub.uni-regensburg.de/9992/1/2009_Lindner_ParvoB19-JCV.pdfTest |
| حقوق: | https://epub.uni-regensburg.de/licenses/lic_without_pod.htmlTest |
| رقم الانضمام: | edsbas.AB398CE |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |