دورية أكاديمية
Canine distemper virus neutralization activity is low in human serum and it is sensitive to an amino acid substitution in the hemagglutinin protein
| العنوان: | Canine distemper virus neutralization activity is low in human serum and it is sensitive to an amino acid substitution in the hemagglutinin protein |
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| المؤلفون: | Zhanga, Xinsheng, Wallace, Olivia L, Domi, Arban, Wright, Kevin J, Driscolla, Jonathan, Anzala, Omu, Sanders, Eduard J, Kamalie, Anatoli, Karita, Etienne, Alleng, Susan, Fasth, Pat, Gilmouri, Jill, Price, Matt A, Parks, Christopher L |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2015 |
| المجموعة: | University of Nairobi Digital Repository |
| مصطلحات موضوعية: | Canine distemper virus, Measles virus, Plaque reduction neutralization test, Neutralizing antibody, Hemagglutinin, Pre-existing immunity, Cross-neutralization |
| الوصف: | Serum was analyzed from 146 healthy adult volunteers in eastern Africa to evaluate measles virus (MV) and canine distemper virus (CDV) neutralizing antibody (nAb) prevalence and potency. MV plaque reduction neutralization test (PRNT) results indicated that all sera were positive for MV nAbs. Furthermore, the 50% neutralizing dose (ND50) for the majority of sera corresponded to antibody titers induced by MV vaccination. CDV nAbs titers were low and generally were detected in sera with high MV nAb titers. A mutant CDV was generated that was less sensitive to neutralization by human serum. The mutant virus genome had 10 nucleotide substitutions, which coded for single amino acid substitutions in the fusion (F) and hemagglutinin (H) glycoproteins and two substitutions in the large polymerase (L) protein. The H substitution occurred in a conserved region involved in receptor interactions among morbilliviruses, implying that this region is a target for cross-reactive neutralizing antibodies |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-0-04-268221-1 0-04-268221-5 |
| العلاقة: | Virology Volume 482, August 2015, Pages 218–224; http://www.sciencedirect.com/science/article/pii/S0042682215001750Test; http://hdl.handle.net/11295/95910Test |
| الإتاحة: | http://hdl.handle.net/11295/95910Test http://www.sciencedirect.com/science/article/pii/S0042682215001750Test |
| حقوق: | Attribution-NonCommercial-ShareAlike 3.0 United States ; http://creativecommons.org/licenses/by-nc-sa/3.0/usTest/ |
| رقم الانضمام: | edsbas.4D1DC2B6 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780042682211 0042682215 |
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