دورية أكاديمية
Medical and dental characteristics of children with chromosome 22q11.2 deletion syndrome at the Royal Children's Hospital, Melbourne
| العنوان: | Medical and dental characteristics of children with chromosome 22q11.2 deletion syndrome at the Royal Children's Hospital, Melbourne |
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| المؤلفون: | Wong, Deborah H., Rajan, Sadna, Hallett, Kerrod B., Manton, David J. |
| المصدر: | Wong , D H , Rajan , S , Hallett , K B & Manton , D J 2021 , ' Medical and dental characteristics of children with chromosome 22q11.2 deletion syndrome at the Royal Children's Hospital, Melbourne ' , International Journal of Paediatric Dentistry . https://doi.org/10.1111/ipd.12755Test |
| سنة النشر: | 2021 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | 22q11.2 deletion syndrome, developmental defects of enamel, enamel hypomineralisation, enamel hypoplasia |
| الوصف: | Background: Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a multifaceted syndrome with a variable phenotype. Few studies have described the associated dental characteristics and their relationship with medical co-morbidities; and no Australian data exist. Aim: To determine the clinical manifestations and correlations between oral and medical conditions in children with 22q11.2DS. Design: A retrospective observational study. Children genetically diagnosed with 22q11.2DS at the Royal Children's Hospital Melbourne were selected; their medical and dental characteristics were collated and analysed. Results: The study population (n = 57; mean age 11.5 years, range 2-27 years) experienced a range of medical conditions involving multiple medical systems; of whom 44 (77.2%) had caries experience, 7 (12.3%) developmentally missing teeth, and 31 (54.4%) developmental defects of enamel (DDE). Smaller proportions of primary teeth were affected by DDE in children with congenital heart disease (2.2% vs 9.7%; P = .02), and cardiac surgery (0.2% vs 9%; P = .001). Conversely, children with hypoparathyroidism (n = 2) had significantly higher proportions of primary teeth affected by DDE (27.5% vs 4%; P = .02). Conclusions: Significant associations existed between medical conditions (congenital heart disease, history of cardiac surgery, and hypoparathyroidism) and primary dentition DDE in children with 22q11.2 DS. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/6fb34a9f-32ca-4c28-9b7d-11694eda7ad8Test |
| DOI: | 10.1111/ipd.12755 |
| الإتاحة: | https://doi.org/10.1111/ipd.12755Test https://hdl.handle.net/11370/6fb34a9f-32ca-4c28-9b7d-11694eda7ad8Test https://research.rug.nl/en/publications/6fb34a9f-32ca-4c28-9b7d-11694eda7ad8Test https://pure.rug.nl/ws/files/156757260/Medical_and_dental_characteristics_of_children_with_chromosome_22q11.2_deletion_syndrome_at_the_Royal_Children_s_Hospital_Melbourne.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.16DA7C64 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/ipd.12755 |
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