دورية أكاديمية
Incidence of PTLD in pediatric renal transplant recipients receiving basiliximab, calcineurin inhibitor, sirolimus and steroids
| العنوان: | Incidence of PTLD in pediatric renal transplant recipients receiving basiliximab, calcineurin inhibitor, sirolimus and steroids |
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| المؤلفون: | McDonald, R. A., Smith, J. M., Ho, M., Lindblad, R., Ikle, D., Grimm, P., Wyatt, R., Arar, M., Liereman, D., Bridges, N., Harmon, W. |
| المصدر: | McDonald , R A , Smith , J M , Ho , M , Lindblad , R , Ikle , D , Grimm , P , Wyatt , R , Arar , M , Liereman , D , Bridges , N , Harmon , W & CCTPT Study Grp 2008 , ' Incidence of PTLD in pediatric renal transplant recipients receiving basiliximab, calcineurin inhibitor, sirolimus and steroids ' , American Journal of Transplantation , vol. 8 , no. 5 , pp. 984-989 . https://doi.org/10.1111/j.1600-6143.2008.02167.xTest |
| سنة النشر: | 2008 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | EBV, pediatric, PTLD, renal transplant, POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER, EPSTEIN-BARR-VIRUS, SINGLE-CENTER, RISK FACTOR, EB VIRUS, IMMUNOSUPPRESSION, ANTIBODIES, INFECTIONS, MALIGNANCY, TACROLIMUS |
| الوصف: | Pediatric renal transplant recipients were enrolled in a multicenter, randomized, double-blind trial of steroid withdrawal. Subjects received basiliximab, calcineurin inhibitor, sirolimus and steroids. Of 274 subjects enrolled, 19 (6.9%) subjects developed posttransplant lymphoproliferative disorder (PTLD). The relative hazard (RH) for PTLD was 5.3-fold higher in children aged 12 years (p = 0.0017). EBV seronegative subjects had a 4.7-fold higher RH compared to EBV positive subjects (p = 0.02). Among EBV donor+/recipient- (D+/R-) subjects, the RH increased by 6.1-fold (p = 0.0001). In a multivariate model, risk factors included recipient age |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/2f644c90-e7a0-4920-99e4-817d1c874111Test |
| DOI: | 10.1111/j.1600-6143.2008.02167.x |
| الإتاحة: | https://doi.org/10.1111/j.1600-6143.2008.02167.xTest https://hdl.handle.net/11370/2f644c90-e7a0-4920-99e4-817d1c874111Test https://research.rug.nl/en/publications/2f644c90-e7a0-4920-99e4-817d1c874111Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.4506DA0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1600-6143.2008.02167.x |
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