Cell biology:MicroRNA expression in zebrafish embryonic development

التفاصيل البيبلوغرافية
العنوان:	Cell biology:MicroRNA expression in zebrafish embryonic development
المؤلفون:	Wienholds, Erno, Kloosterman, Wigard P., Miska, Eric, Alvarez-Saavedra, Ezequiel, Berezikov, Eugene, De Bruijn, Ewart, Horvitz, H. Robert, Kauppinen, Sakari, Plasterk, Ronald H A
المصدر:	Wienholds , E , Kloosterman , W P , Miska , E , Alvarez-Saavedra , E , Berezikov , E , De Bruijn , E , Horvitz , H R , Kauppinen , S & Plasterk , R H A 2005 , ' Cell biology : MicroRNA expression in zebrafish embryonic development ' , Science , vol. 309 , no. 5732 , pp. 310-311 . https://doi.org/10.1126/science.1114519Test
سنة النشر:	2005
المجموعة:	University of Groningen research database
الوصف:	MicroRNAs (miRNAs) are small noncoding RNAs, about 21 nucleotides in length, that can regulate gene expression by base-pairing to partially complementary mRNAs. Regulation by miRNAs can play essential roles in embryonic development. We determined the temporal and spatial expression patterns of 115 conserved vertebrate miRNAs in zebrafish embryos by microarrays and by in situ hybridizations, using locked-nucleic acid-modified oligonucleotide probes. Most miRNAs were expressed in a highly tissue-specific manner during segmentation and later stages, but not early in development, which suggests that their role is not in tissue fate establishment but in differentiation or maintenance of tissue identity.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
العلاقة:	https://research.rug.nl/en/publications/db8d6447-96fd-40e8-b069-83720b4e036fTest
DOI:	10.1126/science.1114519
الإتاحة:	https://doi.org/10.1126/science.1114519Test https://hdl.handle.net/11370/db8d6447-96fd-40e8-b069-83720b4e036fTest https://research.rug.nl/en/publications/db8d6447-96fd-40e8-b069-83720b4e036fTest
حقوق:	info:eu-repo/semantics/closedAccess
رقم الانضمام:	edsbas.B6830510
قاعدة البيانات:	BASE

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الوصف
DOI:	10.1126/science.1114519