دورية أكاديمية
Innovations, challenges, and minimal information for standardization of humanized mice
| العنوان: | Innovations, challenges, and minimal information for standardization of humanized mice |
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| المؤلفون: | Stripecke, Renata, Muenz, Christian, Schuringa, Jan Jacob, Bissig, Karl-Dimiter, Soper, Brian, Meeham, Terrence, Yao, Li-Chin, Di Santo, James P., Brehm, Michael, Rodriguez, Estefania, Wege, Anja Kathrin, Bonnet, Dominique, Guionaud, Silvia, Howard, Kristina E., Kitchen, Scott, Klein, Florian, Saeb-Parsy, Kourosh, Sam, Johannes, Sharma, Amar Deep, Trumpp, Andreas, Trusolino, Livio, Bult, Carol, Shultz, Leonard |
| المصدر: | Stripecke , R , Muenz , C , Schuringa , J J , Bissig , K-D , Soper , B , Meeham , T , Yao , L-C , Di Santo , J P , Brehm , M , Rodriguez , E , Wege , A K , Bonnet , D , Guionaud , S , Howard , K E , Kitchen , S , Klein , F , Saeb-Parsy , K , Sam , J , Sharma , A D , Trumpp , A , Trusolino , L , Bult , C & Shultz , L 2020 , .... |
| سنة النشر: | 2020 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | humanized mice, infections, PDX, immuno-oncology, regenerative medicine, HEMATOPOIETIC STEM-CELLS, BREAST-CANCER CELLS, LIVER CHIMERIC MICE, MOUSE MODEL, HUMAN HEPATOCYTES, IMMUNE-SYSTEM, HEPATITIS-B, ANTIBODY THERAPY, VIRUS-INFECTION, XENOGRAFTS |
| الوصف: | Mice xenotransplanted with human cells and/or expressing human gene products (also known as "humanized mice") recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can provide a relevantin vivocontext for understanding of human-specific physiology and pathologies. Humanized mice have advanced toward mainstream preclinical models and are now at the forefront of biomedical research. Here, we considered innovations and challenges regarding the reconstitution of human immunity and human tissues, modeling of human infections and cancer, and the use of humanized mice for testing drugs or regenerative therapy products. As the number of publications exploring different facets of humanized mouse models has steadily increased in past years, it is becoming evident that standardized reporting is needed in the field. Therefore, an international community-driven resource called "Minimal Information for Standardization of Humanized Mice" (MISHUM) has been created for the purpose of enhancing rigor and reproducibility of studies in the field. WithinMISHUM, we propose comprehensive guidelines for reporting critical information generated using humanized mice. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/f5f03b9b-887b-41fb-bdb0-8c1ae11e92e5Test |
| DOI: | 10.15252/emmm.201708662 |
| الإتاحة: | https://doi.org/10.15252/emmm.201708662Test https://hdl.handle.net/11370/f5f03b9b-887b-41fb-bdb0-8c1ae11e92e5Test https://research.rug.nl/en/publications/f5f03b9b-887b-41fb-bdb0-8c1ae11e92e5Test https://pure.rug.nl/ws/files/144367808/Innovations_challenges_and_minimal_information_for_standardization_of_humanized_mice.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F46368F8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.15252/emmm.201708662 |
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