دورية أكاديمية
Carbapenemase-Producing Klebsiella pneumoniae in Romania:A Six-Month Survey
| العنوان: | Carbapenemase-Producing Klebsiella pneumoniae in Romania:A Six-Month Survey |
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| المؤلفون: | Lixandru, Brandusa Elena, Cotar, Ani Ioana, Straut, Monica, Usein, Codruta Romanita, Cristea, Dana, Ciontea, Simona, Tatu-Chitoiu, Dorina, Codita, Irina, Rafila, Alexandru, Nica, Maria, Buzea, Mariana, Baicus, Anda, Ghita, Mihaela Camelia, Nistor, Irina, Tuchilus, Cristina, Indreas, Marina, Antohe, Felicia, Glasner, Corinna, Grundmann, Hajo, Jasir, Aftab, Damian, Maria |
| المصدر: | Lixandru , B E , Cotar , A I , Straut , M , Usein , C R , Cristea , D , Ciontea , S , Tatu-Chitoiu , D , Codita , I , Rafila , A , Nica , M , Buzea , M , Baicus , A , Ghita , M C , Nistor , I , Tuchilus , C , Indreas , M , Antohe , F , Glasner , C , Grundmann , H , Jasir , A & Damian , M 2015 , ' Carbapenemase-Producing Klebsiella pneumoniae in Romania : A Six-Month Survey .... |
| سنة النشر: | 2015 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | BETA-LACTAMASE, PSEUDOMONAS-AERUGINOSA, ENTEROBACTERIACEAE, PLASMID, SPREAD, RESISTANCE, EMERGENCE, OUTBREAK, STRAINS, TURKEY |
| الوصف: | This study presents the first characterization of carbapenem-non-susceptible Klebsiella pneumoniae isolates by means of a structured six-month survey performed in Romania as part of an Europe-wide investigation. Klebsiella pneumoniae clinical isolates from different anatomical sites were tested for antibiotic susceptibility by phenotypic methods and confirmed by PCR for the presence of four carbapenemase genes. Genome macrorestriction fingerprinting with XbaI was used to analyze the relatedness of carbapenemase-producing Klebsiella pneumoniae isolates collected from eight hospitals. Among 75 non-susceptible isolates, 65 were carbapenemase producers. The most frequently identified genotype was OXA-48 (n = 51 isolates), eight isolates were positive for bla(NDM-1) gene, four had the bla(KPC-2) gene, whereas two were positive for bla(VIM-1). The analysis of PFGE profiles of OXA-48 and NDM-1 producing K. pneumoniae suggests inter-hospitals and regional transmission of epidemic clones. This study presents the first description of K. pneumoniae strains harbouring blaKPC-2 and blaVIM-1 genes in Romania. The results of this study highlight the urgent need for the strengthening of hospital infection control measures in Romania in order to curb the further spread of the antibiotic resistance. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/6bb93036-95cf-4bbc-8207-c91a14475866Test |
| DOI: | 10.1371/journal.pone.0143214 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0143214Test https://hdl.handle.net/11370/6bb93036-95cf-4bbc-8207-c91a14475866Test https://research.rug.nl/en/publications/6bb93036-95cf-4bbc-8207-c91a14475866Test https://pure.rug.nl/ws/files/28400786/journal.pone.0143214.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.2E0DED72 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0143214 |
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