دورية أكاديمية
Association study indicates a protective role of phosphatidylinositol-4-phosphate-5-kinase against tardive dyskinesia
| العنوان: | Association study indicates a protective role of phosphatidylinositol-4-phosphate-5-kinase against tardive dyskinesia |
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| المؤلفون: | Fedorenko, Olga Yu, Loonen, Anton J. M., Lang, Florian, Toshchakova, Valentina A., Boyarko, Evgenia G., Semke, Arkadiy V., Bokhan, Nikolay A., Govorin, Nikolay V., Aftanas, Lyubomir I., Ivanova, Svetlana A. |
| المصدر: | Fedorenko , O Y , Loonen , A J M , Lang , F , Toshchakova , V A , Boyarko , E G , Semke , A V , Bokhan , N A , Govorin , N V , Aftanas , L I & Ivanova , S A 2015 , ' Association study indicates a protective role of phosphatidylinositol-4-phosphate-5-kinase against tardive dyskinesia ' , International Journal of Neuropsychopharmacology , vol. 18 , no. 6 , pp. 1-6 . https://doi.org/10.1093/ijnp/pyu098Test |
| سنة النشر: | 2015 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | gene polymorphism, medium spiny neurons, neurotoxicity, PIP5K2A, schizophrenia, tardive dyskinesia, 1 phosphatidylinositol 4 phosphate 5 kinase type IIa, phosphatidylinositol 4 phosphate kinase, unclassified drug, adult, article, disease severity, female, gene frequency, genetic variability, genotype, human, major clinical study, male, pathophysiology, prevalence, priority journal, single nucleotide polymorphism |
| الوصف: | Background: Tardive dyskinesia is a disorder characterized by involuntary muscle movements that occur as a complication of long-term treatment with antipsychotic drugs. It has been suggested to be related to a malfunctioning of the indirect pathway of the motor part of the cortical-striatal-thalamic-cortical circuit, which may be caused by oxidative stress-induced neurotoxicity. Methods: The purpose of our study was to investigate the possible association between phosphatidylinositol-4-phosphate-5-kinase type IIa (PIP5K2A) function and tardive dyskinesia in 491 Caucasian patients with schizophrenia from 3 different psychiatric institutes in West Siberia. The Abnormal Involuntary Movement Scale was used to assess tardive dyskinesia. Individuals were genotyped for 3 single nucleotide polymorphisms in PIP5K2A gene: rs10828317, rs746203, and rs8341. Results: A significant association was established between the functional mutation N251S-polymorphism of the PIP5K2A gene (rs10828317) and tardive dyskinesia, while the other 2 examined nonfunctional single nucleotide polymorphisms were not related. Conclusions: We conclude from this association that PIP5K2A is possibly involved in a mechanism protecting against tardive dyskinesia-inducing neurotoxicity. This corresponds to our hypothesis that tardive dyskinesia is related to neurotoxicity at striatal indirect pathway medium-sized spiny neurons. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/8f051fb5-0a1b-4228-8f3c-3df1a7780bfdTest |
| DOI: | 10.1093/ijnp/pyu098 |
| الإتاحة: | https://doi.org/10.1093/ijnp/pyu098Test https://hdl.handle.net/11370/8f051fb5-0a1b-4228-8f3c-3df1a7780bfdTest https://research.rug.nl/en/publications/8f051fb5-0a1b-4228-8f3c-3df1a7780bfdTest https://pure.rug.nl/ws/files/55679557/pyu098.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.AC929229 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ijnp/pyu098 |
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