دورية أكاديمية
Use of tolterodine in children with neurogenic detrusor overactivity:Relationship between dose and urodynamic response
| العنوان: | Use of tolterodine in children with neurogenic detrusor overactivity:Relationship between dose and urodynamic response |
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| المؤلفون: | Ellsworth, PI, Borgstein, NG, Nijman, RJM, Reddy, PP |
| المصدر: | Ellsworth , PI , Borgstein , NG , Nijman , RJM & Reddy , PP 2005 , ' Use of tolterodine in children with neurogenic detrusor overactivity : Relationship between dose and urodynamic response ' , Journal of Urology , vol. 174 , no. 4 , pp. 1647-1651 . https://doi.org/10.1097/01.ju.0000176622.81796.89Test ; ISSN:0022-5347 |
| سنة النشر: | 2005 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | child, drug therapy, bladder, neurogenic, muscarinic antagonists, INTERMITTENT CATHETERIZATION, OXYBUTYNIN CHLORIDE, MYELOMENINGOCELE, HYPERREFLEXIA, DYSFUNCTION, THERAPY, INFANTS |
| الوصف: | Purpose: Three exploratory studies were conducted to investigate the pharmacokinetics (PK) and safety of tolterodine in children 1 month to 15 years old with neurogenic detrusor overactivity. We urodynamically evaluated the dose and concentration effects of tolterodine to establish safe and effective dosing regimens. Materials and Methods: Three open-label, dose escalating studies were conducted in children with stable neurological disease and detrusor overactivity. In studies 1 (patient aged 1 month to 4 years) and 2 (5 to 10 years) patients received 0.03, 0.06 and 0.12 mg/kg tolterodine solution day twice daily for 4 weeks each. In study 3 (patient age 11 to 15 years) patients received 2, 4 and 6 mg tolterodine extended-release capsules once daily for 4 weeks each. PK was assessed after 8 weeks, urodynamic assessments were conducted after each 4-week dosing period and 3-day micturition diaries were completed. Results: Patients in studies 1 (19) and 2 (15) showed some dose related increases in volume to first detrusor contraction and cystometric bladder capacity. In study 3 (11 patients) there were no obvious dose-response relationships. PK results from studies 1 and 2 suggest that there was no apparent effect of age ( Conclusions: These results support the safety of age and body weight adjusted dosing regimens for further clinical evaluation of tolterodine in children with neurogenic detrusor overactivity. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1097/01.ju.0000176622.81796.89 |
| الإتاحة: | https://doi.org/10.1097/01.ju.0000176622.81796.89Test http://hdl.handle.net/11370/d59ef3d0-d91a-4cde-9ff7-7df4d692bf04Test https://research.rug.nl/en/publications/use-of-tolterodine-in-children-with-neurogenic-detrusor-overactivityTest(d59ef3d0-d91a-4cde-9ff7-7df4d692bf04).html |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.A8A32B48 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/01.ju.0000176622.81796.89 |
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