دورية أكاديمية
MYOCARDIAL CARBOHYDRATE, KETONE, AND FATTY-ACID UPTAKE IN CONSCIOUS LAMBS WITH AORTOPULMONARY SHUNTS
| العنوان: | MYOCARDIAL CARBOHYDRATE, KETONE, AND FATTY-ACID UPTAKE IN CONSCIOUS LAMBS WITH AORTOPULMONARY SHUNTS |
|---|---|
| المؤلفون: | GRATAMA, JWC, DALINGHAUS, M, MEUZELAAR, JJ, GERDING, AM, KOERS, JH, MUSKIET, FAJ, KUIPERS, JRG |
| المصدر: | GRATAMA , JWC , DALINGHAUS , M , MEUZELAAR , JJ , GERDING , AM , KOERS , JH , MUSKIET , FAJ & KUIPERS , JRG 1992 , ' MYOCARDIAL CARBOHYDRATE, KETONE, AND FATTY-ACID UPTAKE IN CONSCIOUS LAMBS WITH AORTOPULMONARY SHUNTS ' , Pediatric Research , vol. 32 , no. 1 , pp. 27-32 . |
| سنة النشر: | 1992 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | OXYGEN-CONSUMPTION, LACTATE-DEHYDROGENASE, SUBSTRATE UTILIZATION, HEART-FAILURE, BLOOD-FLOW, METABOLISM, EXERCISE, GLUCOSE, OXIDATION, MUSCLE |
| الوصف: | A left to right shunt increases myocardial work and is often accompanied by increased catecholamine levels. Because both increased myocardial work and increased catecholamine levels may induce increased fatty acid utilization, which could increase resting myocardial oxygen consumption and therefore unfavorably affect coronary reserve, we studied myocardial uptake of glucose, pyruvate, lactate, beta-OH-butyrate, acetoacetate, FFA, and triglycerides in 12 7-wk-old lambs with aortopulmonary left to right shunts (58 +/- 2% of left ventricular output. mean +/- SEM) and in 10 control lambs 2 wk after surgery. Despite the shunt, systemic blood flow in the shunt lambs was maintained at the same level as in the control lambs. This was accomplished by an increased heart rate and stroke volume. Furthermore, the shunt was accompanied by an increased myocardial oxygen consumption in the shunt lambs (834 +/- 70 versus 528 +/- 43-mu-mol O2.min-1.100 g-1; p <0.05). There were no significant differences in arterial substrate concentrations between the two groups. The same was true for arteriovenous differences across the myocardium, with the exception of lactate, which was substantially higher in shunt than in control lambs (72 +/- 25 versus 18 +/- 23-mu-mol/L; p <0.05). As a consequence, myocardial lactate uptake in the shunt lambs was increased 15-fold (18 +/- 6 versus 1 +/- 2-mu-mol.min-1.100 g-1; p <0.02), whereas uptake of the other substrates merely paralleled the increased myocardial blood flow. Our data demonstrate that myocardial substrate uptake is not substantially different between shunt and control lambs, with the exception of lactate, of which the extraction is 10-fold higher than in control lambs. We speculate that the increased myocardial lactate utilization may reflect an increase of lactate and pyruvate dehydrogenase activities. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/9d54f460-9006-4079-8ead-a5a65ae718c9Test |
| الإتاحة: | https://hdl.handle.net/11370/9d54f460-9006-4079-8ead-a5a65ae718c9Test https://research.rug.nl/en/publications/9d54f460-9006-4079-8ead-a5a65ae718c9Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.B28EC867 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |