دورية أكاديمية
The association between active tumor volume, total lesion glycolysis and levels of S-100B and LDH in stage IV melanoma patients
| العنوان: | The association between active tumor volume, total lesion glycolysis and levels of S-100B and LDH in stage IV melanoma patients |
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| المؤلفون: | Deckers, E A, Kruijff, S, Brouwers, A H, van der Steen, K, Hoekstra, H J, Thompson, J F, Vállez García, David, Wevers, K P |
| المصدر: | Deckers , E A , Kruijff , S , Brouwers , A H , van der Steen , K , Hoekstra , H J , Thompson , J F , Vállez García , D & Wevers , K P 2020 , ' The association between active tumor volume, total lesion glycolysis and levels of S-100B and LDH in stage IV melanoma patients ' , European Journal of Surgical Oncology , vol. 46 , no. 11 , pp. 2147-2153 . https://doi.org/10.1016/j.ejso.2020.07.011Test |
| سنة النشر: | 2020 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | Melanoma, PET, Biomarkers, S-100B, LDH, Staging, FDG-PET/CT, LACTATE-DEHYDROGENASE, MALIGNANT-MELANOMA, SERUM S-100B, SURVIVAL, GUIDELINES, IPILIMUMAB, DIAGNOSIS, PROTEIN, ASSAYS |
| الوصف: | Introduction: The Standardized Uptake Value (SUV) in single lesions on F-18-FDG PET/CT scans and serum S-100B concentrations are inversely associated with disease-free survival in stage IV melanoma. The aim of this study was to assess the association between biomarkers (S-100B, LDH) and the PET-derived metrics SUVmean/max, metabolic active tumor volume (MATV), and total lesion glycolysis (TLG) in stage IV melanoma in order to understand what these biomarkers reflect and their possible utility for follow-up. Methods: In 52 stage IV patients the association between PET-derived metrics and the biomarkers S-100B and LDH was assessed and the impact on survival analyzed. Results: S-100B was elevated (>0.15 mu g/l) in 37 patients (71%), LDH in 11 (21%). There was a correlation between S-100B and LDH (R-2 = 0.19). S-100B was correlated to both MATV (R-2 = 0.375) and TLG (R-2 = 0.352), but LDH was not. Higher MATV and TLG levels were found in patients with elevated S-100B (p <0.001) and also in patients with elevated LDH (>250 U/l) (p <0.001). There was no association between the biomarkers and SUVmean/max. Survival analysis indicated that LDH was the only predictor of melanoma-specific survival. Conclusion: In newly diagnosed stage IV melanoma patients S-100B correlates with F-18-FDG PET/CT derived MATV and TLG in contrast to LDH, is more often elevated than LDH (71% vs. 21%) and seems to be a better predictor of disease load and disease progression. However, elevated LDH is the only predictor for survival. The biomarkers, S-100B and LDH appear to describe different aspects of the extent of metastatic disease and of tumornecrosis. (C) 2020 The Authors. Published by Elsevier Ltd. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/2b02e666-5947-499c-b576-a401e4a08c07Test |
| DOI: | 10.1016/j.ejso.2020.07.011 |
| الإتاحة: | https://doi.org/10.1016/j.ejso.2020.07.011Test https://hdl.handle.net/11370/2b02e666-5947-499c-b576-a401e4a08c07Test https://research.rug.nl/en/publications/2b02e666-5947-499c-b576-a401e4a08c07Test https://pure.rug.nl/ws/files/156760140/The_association_between_active_tumor_volume_total_lesion_glycolysis_and_levels_of_S_100B_and_LDH_in_stage_IV_melanoma_patients.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8B049FC5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ejso.2020.07.011 |
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