دورية أكاديمية
DIAGNOSTIC-VALUE OF ANTIBODIES AGAINST RIBOSOMAL PHOSPHOPROTEINS - A CROSS-SECTIONAL AND LONGITUDINAL-STUDY
| العنوان: | DIAGNOSTIC-VALUE OF ANTIBODIES AGAINST RIBOSOMAL PHOSPHOPROTEINS - A CROSS-SECTIONAL AND LONGITUDINAL-STUDY |
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| المؤلفون: | VANDAM, A, NOSSENT, H, DEJONG, J, MEILOF, J, TERBORG, EJ, SWAAK, T, SMEENK, R |
| المصدر: | VANDAM , A , NOSSENT , H , DEJONG , J , MEILOF , J , TERBORG , EJ , SWAAK , T & SMEENK , R 1991 , ' DIAGNOSTIC-VALUE OF ANTIBODIES AGAINST RIBOSOMAL PHOSPHOPROTEINS - A CROSS-SECTIONAL AND LONGITUDINAL-STUDY ' , Journal of Rheumatology , vol. 18 , no. 7 , pp. 1026-1034 . |
| سنة النشر: | 1991 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | SLE, ANTI-P ANTIBODIES, LUPUS PSYCHOSIS, LONGITUDINAL STUDY, SYSTEMIC LUPUS-ERYTHEMATOSUS, CONNECTIVE-TISSUE DISEASE, VERSUS-HOST DISEASE, DOUBLE-STRANDED DNA, ANTI-DSDNA, ANTINUCLEAR ANTIBODIES, MURINE MODELS, P-ANTIBODIES, PROTEIN, AUTOANTIBODIES |
| الوصف: | Antibodies against ribosomal phosphoproteins (anti-P antibodies) are found in about 10% of patients with systemic lupus erythematosus (SLE). Using an ELISA with a synthetic peptide for screening and an immunoblotting technique as a confirmation test for detection of these antibodies, we found 16 positive patients among 946 sera sent to our reference laboratory for anti-DNA determination. All 12 patients on which we could obtain clinical data had clearcut SLE, fulfilling 6 ARA criteria on average. Skin symptoms were observed more frequently in anti-P positive than in anti-P negative patients with SLE. We also tested 56 sera from 54 patients with well defined SLE during monosymptomatic exacerbations and found and identical frequency of about 10% of anti-P antibodies in groups of patients with different types of exacerbation, including psychosis. A retrospective analysis of 9 patients followed 3-10 years showed that they all were already positive for anti-P at the onset of disease. In total these patients showed 15 major peaks in anti-P levels (defined as at least a 4-fold rise in titer in a period of 3 months). Five of the fluctuations in anti-P levels were paralleled by fluctuations in anti-DNA levels. In 6/15 cases, peaks of anti-P levels were accompanied by an exacerbation of SLE, but only 2 peaks of anti-P levels were already detectable before the onset of the exacerbation. In addition, 6 other exacerbations occurred in the absence of major anti-P rises in the preceding 3 months. Therefore, quantitative determinations of anti-P have at most a limited practical value in the followup of patients with SLE. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/c8ee4762-e28b-4b59-8c26-71350e2f4ea4Test |
| الإتاحة: | https://hdl.handle.net/11370/c8ee4762-e28b-4b59-8c26-71350e2f4ea4Test https://research.rug.nl/en/publications/c8ee4762-e28b-4b59-8c26-71350e2f4ea4Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.9D80D2CA |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |