-
1تقرير
المؤلفون: 松本 英樹, Matsumoto H
مصطلحات موضوعية: Bystander effect, Adaptive response, Hyperradiosensitivity, nitric oxide, p53
الوصف: There has been a recent upsurge of interest in radiation-induced adaptive response and bystander effect, which are specific modes in stress response to low-dose/low-dose rate radiation. Previously we reported that the accumulation of inducible nitric oxide(NO)synthase(iNOS)was induced only in human glioblastoma mutant(m)p53 cells by acute irradiation with X-rays, suggesting a suppression of iNOS induction after acute irradiation with X-rays in wild-type(wt)p53 cells. NO secreted from the irradiated mp53 cells induced the accumulation of p53 in unirradiated wtp53 ce11s. The radiosensitivity of wtp53 cells was reduced by exposure to the conditioned medium from irradiated mp53 cells, suggesting that NO is an initiator of radiation-induced bystander effects. Recently, we found that the accumulation of iNOS in wtp53 cells was induced by chronic irradiation with gamma rays followed by acute irradiation with X-rays, but not by each one,resulting in an increase in nitrite concentrations of medium. it is suggested that the accumulation of iNOS may be due to the depression of acute irradiation-induced p53 functions by pre-chronic irradiation. We found that the radiosensitivity of wtp53 cells against acute irradiation with X-rays was reduced after chronic irradiation with gamma rays. This reduction of radiosensitivity of wtp53 cells is just radiationinduced adaptive response, suggesting that NO-mediated bystander effect may considerably contribute to adaptive response induced by radiation.
العلاقة: https://u-fukui.repo.nii.ac.jp/?action=repository_uri&item_id=20415Test; http://hdl.handle.net/10098/1057Test; 癌の臨床, 50(13), 1075-1079(2004-12); 214949; TD00006256; https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=20415&item_no=1&attribute_id=22&file_no=1Test
-
2تقرير
المؤلفون: 松本 英樹, Matsumoto H
مصطلحات موضوعية: Cancer, p53, Mutation, Loss-of-function, Gain-of-function
الوصف: The tumor suppressor gene, p53 plays a central role in the protection against DNA damage and other forms of physiological stress primarily by inducing cell cycle arrest or apoptosis. Mutation of p53, Which is the most frequent genetic alteration detected in human cancers, inactivates these growth regulatory functions and causes a loss of tumor suppressor activity.In some cases,the mutation also confers tumor-promoting functions, such as the transcriptional activation of genes invoIved in cell proliferation, cell survival and angiogenesis.Consequently, cell expressing some forms of mutant p53 show enhanced tumorigenic potential with increased resistance to anti-cancer drugs and radiation.
العلاقة: https://u-fukui.repo.nii.ac.jp/?action=repository_uri&item_id=20406Test; http://hdl.handle.net/10098/1056Test; 癌の臨床, 49(12), 1519-1523(2003-11); 214949; TD00006253; https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=20406&item_no=1&attribute_id=22&file_no=1Test
-
3تقرير
المؤلفون: 松本 英樹, 加納 永一, Matsumoto H, Kano E
مصطلحات موضوعية: Radiation, Bystander effect, Nitric oxide, p53, Radiotherapy
الوصف: Nitric oxide and its metabolites such as peroxynitrite and nitric dioxide cause DNA damage and protein modifications.In addition,nitric oxide can induce p53 accumulation.As part of a feedback loop,p53 mediates transcriptional transrepression of inducible nitric oxide synthase.Recent studies have suggested the interactive effects of nitric oxide and p53 on cellular sensitivity against cancer therapeutic agents.This review summarizes current knowledge,including our findings,of the roles of nitric oxide in cellular response to cancer therapeutic agents,in particular radiation-induced bystander effect and the invoIvement of the p53 gene status in this regard.
العلاقة: https://u-fukui.repo.nii.ac.jp/?action=repository_uri&item_id=20417Test; http://hdl.handle.net/10098/1058Test; 癌の臨床, 47(1), 8-11(2001-01); 214949; TD00006257; https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=20417&item_no=1&attribute_id=22&file_no=1Test
