التفاصيل البيبلوغرافية
| العنوان: |
The impact of hemoglobin oxidation in NLRP3 inflammasome activation upon intravascular hemolysis |
| المؤلفون: |
Nyakundi, Bogonko Benard |
| المساهمون: |
Viktoria, Jeney, Molekuláris sejt- és immunbiológia doktori iskola, DE--Általános Orvostudományi Kar -- Research Centre for Molecular Medicine |
| سنة النشر: |
2020 |
| المجموعة: |
University of Debrecen Electronic Archive (DEA) / Debreceni Egyetem elektronikus Archívum |
| مصطلحات موضوعية: |
hemolysis, hemoglobin, inflammasome activation, Elméleti orvostudományok, Orvostudományok |
| الوصف: |
In this work, we demonstrated that following intravascular hemolysis Hb oxidation leads to the formation of hemichrome, metHb, covalently cross-linked Hb multimers, and free heme. We showed that PHZ-induced IVH triggers IL-1 production via the NLRP3 inflammasome activation. We demonstrated that covalently cross-linked Hb forms during the decomposition of transient ferrylHb the molecules we proposed to name as gmoxHb. We Identified gmoxHb as a potent pro-inflammatory Hb form which induced the active production of IL-1 in vivo and in vitro. We confirmed that NLRP3 deficiency confers a survival advantage to mice in PHZ-induced IVH via increased tolerance and improved tissue damage control mechanisms. Identification of RBC-derived DAMPs and understanding the signaling mechanisms involved in the pathophysiology might provide new approaches for the treatment of IVH-related pathological conditions. |
| نوع الوثيقة: |
other/unknown material |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://hdl.handle.net/2437/293794Test |
| الإتاحة: |
http://hdl.handle.net/2437/293794Test |
| رقم الانضمام: |
edsbas.A6C050C4 |
| قاعدة البيانات: |
BASE |
