دورية أكاديمية
Randomized comparison of early supplemental oxygen versus ambient air in patients with confirmed myocardial infarction : Sex-related outcomes from DETO2X-AMI
| العنوان: | Randomized comparison of early supplemental oxygen versus ambient air in patients with confirmed myocardial infarction : Sex-related outcomes from DETO2X-AMI |
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| المؤلفون: | Alfredsson, J., James, S. K., Erlinge, D., Herlitz, Johan, Fröbert, O., Dworeck, C., Redfors, B., Arefalk, G., Östlund, O., Jernberg, T., Mars, K., Haaga, U., Lindahl, B., Swahn, E., Lawesson, S. S., Hofmann, R., Investigators, for the DETO2X-SWEDEHEART |
| بيانات النشر: | Högskolan i Borås, Akademin för vård, arbetsliv och välfärd Department of Health, Medicine and Caring Sciences and Department of Cardiology, Linköping University, Linköping, Sweden Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden Department of Clinical Sciences, Cardiology, Lund University, Lund, Sweden Department of Cardiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden Department of Molecular and Clinical Medicine and Sahlgrenska University Hospital, Department of Cardiology, University of Gothenburg, Gothenburg, Sweden Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden Department of Clinical Sciences, Cardiology, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden Department of Clinical Science and Education, Division of Cardiology, Karolinska Institutet-Södersjukhuset, Stockholm, Sweden Department of Cardiology, Karlstad Central Hospital, Karlstad, Sweden Mosby Inc. |
| سنة النشر: | 2021 |
| المجموعة: | University of Borås (DiVA) |
| مصطلحات موضوعية: | acetylsalicylic acid, angiotensin receptor antagonist, beta adrenergic receptor blocking agent, calcium channel blocking agent, clopidogrel, dipeptidyl carboxypeptidase inhibitor, diuretic agent, oxygen, prasugrel, ticagrelor, acute heart infarction, adult, aged, all cause mortality, ambient air, Article, cardiovascular function, cause of death, clinical outcome, comparative study, controlled study, female, follow up, heart failure, hospital readmission, hospitalization, human, incidence, long term care, major clinical study |
| الوصف: | Background: The purpose of this study is to investigate the impact of oxygen therapy on cardiovascular outcomes in relation to sex in patients with confirmed myocardial infarction (MI). Methods: The DETermination of the role of Oxygen in suspected Acute Myocardial Infarction trial randomized 6,629 patients to oxygen at 6 L/min for 6-12 hours or ambient air. In the present subgroup analysis including 5,010 patients (1,388 women and 3,622 men) with confirmed MI, we report the effect of supplemental oxygen on the composite of all-cause death, rehospitalization with MI, or heart failure at long-term follow-up, stratified according to sex. Results: Event rate for the composite endpoint was 18.1% in women allocated to oxygen, compared to 21.4% in women allocated to ambient air (hazard ratio [HR] 0.83, 95% confidence interval [CI] 0.65-1.05). In men, the incidence was 13.6% in patients allocated to oxygen compared to 13.3% in patients allocated to ambient air (HR 1.03, 95% CI 0.86-1.23). No significant interaction in relation to sex was found (P=.16). Irrespective of allocated treatment, the composite endpoint occurred more often in women compared to men (19.7 vs 13.4%, HR 1.51; 95% CI, 1.30-1.75). After adjustment for age alone, there was no difference between the sexes (HR 1.06, 95% CI 0.91-1.24), which remained consistent after multivariate adjustment. Conclusion: Oxygen therapy in normoxemic MI patients did not significantly affect all-cause mortality or rehospitalization for MI or heart failure in women or men. The observed worse outcome in women was explained by differences in baseline characteristics, especially age |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | American Heart Journal, 0002-8703, 2021, 237, s. 13-24; orcid:0000-0003-4139-6235; http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-25907Test; PMID 33689730; ISI:000657580200003; Scopus 2-s2.0-85104119865 |
| DOI: | 10.1016/j.ahj.2021.03.001 |
| الإتاحة: | https://doi.org/10.1016/j.ahj.2021.03.001Test http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-25907Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B24063AF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ahj.2021.03.001 |
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