دورية أكاديمية
TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy
| العنوان: | TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy |
|---|---|
| المؤلفون: | Baumgarten, Anna, Bang, Claudia, Tschirner, Anika, Engelmann, Anke, Adams, Volker, von Haehling, Stephan, Doehner, Wolfram, Pregla, Reinhard, Anker, Markus S., Blecharz, Kinga, Meyer, Rudolf, Hetzer, Roland, Anker, Stefan D., Thum, Thomas, Springer, Jochen |
| المساهمون: | Charité Medical School, Medical School Hannover, Heart Center Leipzig, German Heart Center Berlin, IRCCS San Raffaele, University of East Anglia |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2013 |
| المجموعة: | University of Bedfordshire Repository |
| مصطلحات موضوعية: | TWIST1, ubiquitin proteasome system, dilated cardiomyopathy, transcription, Adult, Animals, Newborn, Cardiomyopathy, Dilated, Female, Humans, Male, MicroRNAs, Middle Aged, Nuclear Proteins, Proteasome Endopeptidase Complex, Rats, Twist Transcription Factor, Ubiquitin |
| الوصف: | The transcription factor TWIST1 has been described to regulate the microRNA (miR)-199/214 cluster. Genetic disruption of TWIST1 resulted in a cachectic phenotype and early death of the knock-out mice. This might be connected to the activity of the ubiquitin-proteasome-system (UPS), as miR-199a has been suggested to regulate the ubiquitin E2 ligases Ube2i and Ube2g1. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1874-1754 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S0167527313000053Test; Baumgarten, A. et al (2013) 'TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy' Int. J. Cardiol. 168 (2):1447-52; http://hdl.handle.net/10547/593473Test; International journal of cardiology |
| DOI: | 10.1016/j.ijcard.2012.12.094 |
| الإتاحة: | https://doi.org/10.1016/j.ijcard.2012.12.094Test http://hdl.handle.net/10547/593473Test |
| حقوق: | Archived with thanks to International journal of cardiology |
| رقم الانضمام: | edsbas.2EC4BFF9 |
| قاعدة البيانات: | BASE |
| تدمد: | 18741754 |
|---|---|
| DOI: | 10.1016/j.ijcard.2012.12.094 |