دورية أكاديمية
Regulation of fatty acid binding proteins by hypoxia inducible factors 1α and 2α in the placenta: Relevance to pre-eclampsia
| العنوان: | Regulation of fatty acid binding proteins by hypoxia inducible factors 1α and 2α in the placenta: Relevance to pre-eclampsia |
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| المؤلفون: | Jadoon, Ayesha, Cunningham, Phil, McDermott, Lindsay C. |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2018 |
| المجموعة: | University of Bedfordshire Repository |
| مصطلحات موضوعية: | n-3 polyunsaturated fatty acids, pre-eclampsia, fatty acid binding proteins, hypoxia, long chain polunsatured fatty acids, hypoxia-inducible factor-1 alpha, placenta |
| الوصف: | Pre-eclampsia is characterized by placental hypoxia and dyslipidemia. Arachidonic and docosahexanoic acids are essential maternal nutrients for fetal development. They are transported via placental trophoblast cells by membrane and cytosolic fatty acid binding proteins. Others report the expressions of these proteins which are increased in hypoxic trophoblasts. Using bioinformatics, BeWo cells, reporter assays, quantitative real-time PCR and immunoblotting we tested the hypothesis that hypoxia inducible factors 1α (HIF-1α) and/ or 2α (HIF-2α) regulate the expressions of FABP1, FABP3, FABP4 and FATP2 proteins. Three hypoxia responsive elements (HRE) were identified in FABP1 which cumulatively responded strongly to HIF-1α and weakly to HIF-2α. FABP3 expression partially responded to HIF-1α. Two putative HRE were validated in FABP4 both of which responded weakly toHIF-1α and HIF-2α. FATP2 protein expression reacted positively to hypoxia. Thus, fetal essential fatty acid supply via the placenta is protected under hypoxia. It will be interesting to determine if our findings are replicated in human pre-eclamptic placenta. ; EPSRC DTA award EP/P504961/1 ; before April 2016 so no file required |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0952-3278 |
| العلاقة: | http://www.plefa.com/article/S0952-3278Test(14)00148-3/fulltext; Jadoon A, Cunningham P, McDermott LC (2014) 'Regulation of fatty acid binding proteins by hypoxia inducible factors 1α and 2α in the placenta: Relevance to pre-eclampsia', Prostaglandins, Leukotrienes and Essential Fatty Acids, 93, pp.25-29.; http://hdl.handle.net/10547/622561Test; Prostaglandins, Leukotrienes and Essential Fatty Acids |
| DOI: | 10.1016/j.plefa.2014.09.004 |
| الإتاحة: | https://doi.org/10.1016/j.plefa.2014.09.004Test http://hdl.handle.net/10547/622561Test |
| حقوق: | Green - can archive pre-print and post-print or publisher's version/PDF |
| رقم الانضمام: | edsbas.91EBA179 |
| قاعدة البيانات: | BASE |
| تدمد: | 09523278 |
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| DOI: | 10.1016/j.plefa.2014.09.004 |