دورية أكاديمية
Triazoles and Their Derivatives : Chemistry, Synthesis, and Therapeutic Applications
| العنوان: | Triazoles and Their Derivatives : Chemistry, Synthesis, and Therapeutic Applications |
|---|---|
| المؤلفون: | Mohammed Mahbubul, Matin, Priyanka, Matin, Md. Rezaur, Rahman, Taibi Ben, Hadda, Faisal A., Almalki, Shafi, Mahmud, Mohammed M, Ghoneim, Maha, Alruwaily, Sultan, Alshehri |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2022 |
| المجموعة: | Universiti Teknologi Mara (UiTM) Digital Repository |
| مصطلحات موضوعية: | TP Chemical technology |
| الوصف: | Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. Structurally, there are two types of five-membered triazoles: 1,2,3-triazole and 1,2,4-triazole. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities. These are also important in organocatalysis, agrochemicals, and materials science. Thus, they have a broad range of therapeutic applications with ever-widening future scope across scientific disciplines. However, adverse events such as hepatotoxicity and hormonal problems lead to a careful revision of the azole family to obtain higher efficacy with minimum side effects. This review focuses on the structural features, synthesis, and notable therapeutic applications of triazoles and related compounds |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | http://ir.unimas.my/id/eprint/38778/1/Triazoles%20-%20Copy.pdfTest; Mohammed Mahbubul, Matin and Priyanka, Matin and Md. Rezaur, Rahman and Taibi Ben, Hadda and Faisal A., Almalki and Shafi, Mahmud and Mohammed M, Ghoneim and Maha, Alruwaily and Sultan, Alshehri (2022) Triazoles and Their Derivatives : Chemistry, Synthesis, and Therapeutic Applications. Frontiers in Molecular Biosciences, 9 (864286). pp. 1-8. ISSN 2296-889X |
| DOI: | 10.3389/fmolb.2022.864286/full |
| DOI: | 10.3389/fmolb.2022.864286 |
| الإتاحة: | https://doi.org/10.3389/fmolb.2022.864286Test http://ir.unimas.my/id/eprint/38778Test/ http://ir.unimas.my/id/eprint/38778/1/Triazoles%20-%20Copy.pdfTest |
| رقم الانضمام: | edsbas.4377099B |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fmolb.2022.864286/full |
|---|