التفاصيل البيبلوغرافية
| العنوان: |
The effects of Momordica charantia and cinnamon extracts on glucose uptake and adiponectin secretion in 3T3-L1 adipose cells / |
| المؤلفون: |
Roffey, Ben. |
| بيانات النشر: |
McGill University |
| سنة النشر: |
2006 |
| المجموعة: |
Theses Canada / Thèses Canada (Library and Archives Canada) |
| مصطلحات موضوعية: |
Momordica charantia, Cinnamon, Non-insulin-dependent diabetes, Hypoglycemic agents |
| الوقت: |
Master of Science (School of Dietetics and Human Nutrition.) |
| الوصف: |
To examine the effects of Momordica charantia (MC) and cinnamon on glucose uptake and adiponectin secretion (AS) fat cells, 3T3-L1 adipocytes were treated with a water extract of cinnamon (CE) and three concentrations of MC water and ethanol extracts. The treatment combination of 0.2 mg/ml MC water extract and 0.5 nM insulin was associated with an increased glucose uptake into the cells (61%) and increased AS from the cells (75%). Without insulin, 0.2 mg/ml of CE increased glucose uptake (100%) and completely inhibited AS from the cells. Sub-optimal concentrations of insulin did not further enhance the CE activity and, in combination with 50 nM insulin, a dose-dependent decrease in glucose uptake was observed. The present results indicate that preferentially water-soluble component(s) in MC enhance the glucose uptake action of sub-optimal concentrations of insulin in 3T3-L1 adipocytes. This effect is accompanied by and may be a result of increased AS. CE increases glucose uptake in these adipocytes but inhibits AS. |
| نوع الوثيقة: |
thesis |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
alephsysno: 002487966; proquestno: AAIMR24783; Theses scanned by UMI/ProQuest.; http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98782Test |
| الإتاحة: |
http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98782Test |
| حقوق: |
© Ben Roffey, 2006 |
| رقم الانضمام: |
edsbas.1B6F756C |
| قاعدة البيانات: |
BASE |
