دورية أكاديمية
Fatal acute haemolysis and methaemoglobinaemia in a man with renal failure and Alkaptonuria - Is nitisinone the solution?
| العنوان: | Fatal acute haemolysis and methaemoglobinaemia in a man with renal failure and Alkaptonuria - Is nitisinone the solution? |
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| المؤلفون: | Davison, AS, Luangrath, E, Selvi, E, Ranganath, LR |
| بيانات النشر: | Elsevier BV |
| سنة النشر: | 2020 |
| المجموعة: | The University of Liverpool Repository |
| الوصف: | Haemolysis and methaemoglobinaemia (MetHb) are rare metabolic complications that can occur in Alkaptonuria (AKU), for which there is no curative treatment. Presented is a case of a man who had AKU, and serves as a reminder of life-threatening complications that can occur with haemolysis and MetHb. This case presents an opportunity to revisit important considerations relating to the investigation and treatment of haemolysis and MetHb with a view to raising awareness, and in doing so hopefully reducing the uniformly fatal outcome. Additionally it is proposed that treatment of haemolysis and MetHb with nitisinone is considered as a potentially lifesaving treatment as it is believed that reducing the concentration of circulating homogentisic acid will reduce oxidative stress. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | http://livrepository.liverpool.ac.uk/3089171/1/Fatal%20acute%20haemolysis%20and%20methaemoglobinaemia%20in%20a%20man%20with%20renal%20failure%20and%20Alkaptonuria%20-%20Is%20nitisinone%20the%20solution.pdfTest; Davison, AS orcid:0000-0001-5501-4475 , Luangrath, E, Selvi, E and Ranganath, LR (2020) Fatal acute haemolysis and methaemoglobinaemia in a man with renal failure and Alkaptonuria - Is nitisinone the solution? Molecular genetics and metabolism reports, 23. p. 100588. |
| DOI: | 10.1016/j.ymgmr.2020.100588 |
| الإتاحة: | https://doi.org/10.1016/j.ymgmr.2020.100588Test http://livrepository.liverpool.ac.uk/3089171Test/ http://livrepository.liverpool.ac.uk/3089171/1/Fatal%20acute%20haemolysis%20and%20methaemoglobinaemia%20in%20a%20man%20with%20renal%20failure%20and%20Alkaptonuria%20-%20Is%20nitisinone%20the%20solution.pdfTest |
| رقم الانضمام: | edsbas.29447856 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ymgmr.2020.100588 |
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