التفاصيل البيبلوغرافية
| العنوان: |
INVESTIGATIONS INTO THE STEREOCHEMICAL AND GLUTAMATERGIC MECHANISMS OF THE 'BATH SALTS' SYNTHETIC CATHINONES MEPHEDRONE AND MDPV IN RATS |
| المؤلفون: |
Gregg, Ryan Alexander |
| المساهمون: |
Rawls, Scott M., Unterwald, Ellen M., Ward, Sara J., Kirby, Lynn, Baumann, Michael H., Ashby, Barrie |
| بيانات النشر: |
Temple University Libraries |
| سنة النشر: |
2015 |
| المجموعة: |
Temple University Digital Collections |
| مصطلحات موضوعية: |
Pharmacology, Neurosciences, Medicine, addiction, glutamate, MDPV, Mephedrone, stereochemistry, Synthetic cathinones |
| الوصف: |
Pharmacology ; Ph.D. ; Synthetic cathinones, commonly referred to as “bath salts”, are a subgroup of novel psychoactive substances that have seen a dramatic rise in abuse worldwide over the past decade. These compounds are synthesized by clandestine drug manufacturers using basic medicinal chemistry techniques, and marketed as “legal high” alternatives to illicit psychostimulants (ie. cocaine and MDMA). Two of the most common synthetic cathinones since the emergence of this class of drugs are 4-methylmethcathinone (mephedrone, MEPH) and 3,4-methylenedioxypyrovalerone (MDPV). The novelty of these compounds in the illicit drug marketplace has limited the current understanding of synthetic cathinone neuropharmacology. Our studies, as outlined in this dissertation, aimed to further characterize the neuropharmacology of MEPH and MDPV, specifically evaluating the contributions of stereospecific mechanisms in the monoaminergic systems, as well as the role of the glutamatergic system in mitigating reward, reinforcement, and relapse to drug seeking. We first evaluated MEPH’s ability to produce behavioral sensitization (detailed in Chapter 2), a hallmark behavior of psychostimulants involving repeated, intermittent drug administration, followed by a period of drug abstinence, and a subsequent drug challenge. This evaluation of MEPH’s ability to produce behavioral sensitization was conducted across multiple treatment and dosing paradigms, withdrawal time point intervals, and drug administration contexts. A 7-day, variable-dose administration paradigm (Days 1+7= 15 mg/kg, Days 2-6= 30 mg/kg) and a 5-day, constant-dose administration paradigm (15 mg/kg) both induced enhancement of repetitive movements (i.e. stereotypy), but not ambulatory activity, during a challenge dose following 10 days of drug abstinence. Additionally, with the 7-day variable-dose design, sensitization of repetitive movements was observed following a shorter (2-day) abstinence interval, and before the initiation of MEPH abstinence on Day 7 of MEPH ... |
| نوع الوثيقة: |
thesis |
| وصف الملف: |
Application/PDF |
| اللغة: |
English |
| العلاقة: |
http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/354278Test |
| الإتاحة: |
http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/354278Test |
| حقوق: |
The author has granted Temple University a limited, non-exclusive, royalty-free license to reproduce his or her dissertation, in whole or in part, in electronic or paper form and to make it available to the general public at no charge. This permission is granted in addition to rights granted to ProQuest. The author retains all other rights. |
| رقم الانضمام: |
edsbas.378D0245 |
| قاعدة البيانات: |
BASE |
