دورية أكاديمية
A study on factors associated with clomifene resistance in infertile women with WHO group II anovulation at a teaching hospital in Sri Lanka
| العنوان: | A study on factors associated with clomifene resistance in infertile women with WHO group II anovulation at a teaching hospital in Sri Lanka |
|---|---|
| المؤلفون: | Palihawadana, T S, Dissanayake, D M A B, Wijesinghe, P S, Seneviratne, H R |
| المصدر: | Sri Lanka Journal of Obstetrics and Gynaecology; Vol 36, No 3 (2014); 71-73 |
| بيانات النشر: | Sri Lanka college of Obstetricians & Gynaecologists |
| سنة النشر: | 2014 |
| المجموعة: | Sri Lanka Journals Online (SLJOL) |
| مصطلحات موضوعية: | Obstetrics & Gynaecology, Anovulation, Female infertility, Polycystic Ovary Syndrome, Treatment, Clomifene, Drug resistance |
| جغرافية الموضوع: | Sri Lanka |
| الوصف: | Background: Anovulation is a common cause of infertility and induction of ovulation with oral agents such as clomifene is the treatment of choice in women with normogonadotropic anovulation. While such treatment is able to achieve ovulation in many, some women fail to respond thus termed as having clomifene resistance. Knowledge on factors associated with such resistance would enable us to counsel patients more accurately and offer alternative treatment modalities without undue delays. This study was aimed at identifying factors associated with clomifene resistance among infertile women with WHO group II anovulation at a teaching hospital in Sri Lanka. Method: A case control study was done at the Infertility clinic of the North Colombo teaching hospital, Ragama conducted by the department of obstetrics & Gynaecology of the University of Kelaniya. Women with WHO group II anovulation (n=128) were included and underwent induction of ovulation with clomifene citrate starting at a dose of 50mg per day, increased up to 150mg till ovulation was achieved. Those who fail to respond to a maximum dose of 150mg were termed as clomifene resistant. The factors known to be associated with clomifene resistance were compared between the two groups who responded and those who failed to respond. The study was registered with the Sri Lankan clinical trial registry maintained by the Sri Lanka Medical association. The study was funded by the National Science foundation of Sri Lanka through a research grant (Grant No: RG/2007/HS/08) Results: Ovulation was achieved in 77.3% (n=99) of subjects and therefore the prevalence of clomifene resistance was 22.8% (n=29). Among those who responded, 41 did so at a dose of 50mg per day while 40% did with 100mg, thus over 80% achieving ovulation at a dose of 100mg per day or less. The factors associated with clomifene resistance in this population included infertility of more than three years (OR 2.06, 95%CI 1.51-9.14), presence of hirsutism (OR 2.76, 95%CI 1.18-6.46), a higher AFC (16 vs 13, ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://www.sljol.info/index.php/SLJOG/article/view/7715/5865Test; http://www.sljol.info/index.php/SLJOG/article/view/7715Test |
| DOI: | 10.4038/sljog.v36i3.7715 |
| الإتاحة: | https://doi.org/10.4038/sljog.v36i3.7715Test http://www.sljol.info/index.php/SLJOG/article/view/7715Test |
| رقم الانضمام: | edsbas.87D63B6F |
| قاعدة البيانات: | BASE |
| DOI: | 10.4038/sljog.v36i3.7715 |
|---|