دورية أكاديمية
The impact of acute preoperative beta-blockade on perioperative cardiac morbidity and all-cause mortality in hypertensive South African vascular surgery patients
| العنوان: | The impact of acute preoperative beta-blockade on perioperative cardiac morbidity and all-cause mortality in hypertensive South African vascular surgery patients |
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| المؤلفون: | Moodley, Y, Biccard, B M |
| المصدر: | South African Medical Journal; Vol 105, No 6 (2015); 476-479 ; 2078-5135 ; 0256-9574 |
| بيانات النشر: | South African Medical Association |
| سنة النشر: | 2015 |
| المجموعة: | South African Medical Journal (SAMJ) |
| مصطلحات موضوعية: | Preoperative, Beta-blockers, Vascular, Outcomes |
| الوصف: | Background. Acute β-blockade has been associated with poor perioperative outcomes in non-cardiac surgery patients, probably as a result of β-blocker-induced haemodynamic instability during the perioperative period, which has been shown to be more severe in hypertensive patients.Objective. To determine the impact of acute preoperative β-blockade on the incidence of perioperative cardiovascular morbidity and allcause mortality in hypertensive South African (SA) patients who underwent vascular surgery at a tertiary hospital.Methods. We conducted two separate case-control analyses to determine the impact of acute preoperative β-blockade on the incidence of major adverse cardiovascular events (MACEs, a composite outcome of a perioperative troponin-I leak or all-cause mortality) and perioperative troponin-I leak alone. Case and control groups were compared using χ2, Fisher’s exact, McNemar’s or Student’s t-tests, where applicable. Binary logistic regression was used to determine whether acute preoperative β-blocker use was an independent predictor of perioperative MACEs/troponin-I leak in hypertensive SA vascular surgery patients.Results. We found acute preoperative β-blockade to be an independent predictor of perioperative MACEs (odds ratio (OR) 3.496; 95% confidence interval (CI) 1.948 - 6.273; p<0.001) and troponin-I leak (OR 5.962; 95% CI 3.085 - 11.52; p<0.001) in hypertensive SA vascular surgery patients.Conclusions. Our findings suggest that acute preoperative β-blockade is associated with an increased risk of perioperative cardiac morbidity and all-cause mortality in hypertensive SA vascular surgery patients. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://samj.org.za/index.php/samj/article/view/10028/6787Test; http://samj.org.za/index.php/samj/article/view/10028Test |
| DOI: | 10.7196/SAMJ.8856 |
| الإتاحة: | https://doi.org/10.7196/SAMJ.8856Test http://samj.org.za/index.php/samj/article/view/10028Test |
| حقوق: | Copyright of published material remains in the Authors’ name. This allows authors to use their work for their own non-commercial purposes without seeking permission from the Publisher, subject to properly acknowledging the Journal as the original place of publication. Authors are free to copy, print and distribute their articles, in full or in part, for teaching activities, and to deposit or include their work in their own personal or institutional database or on-line website. Authors are requested to inform the Journal/Publishers of their desire/intention to include their work in a thesis or dissertation or to republish their work in any derivative form (but not for commercial use). Material submitted for publication in the SAMJ is accepted provided it has not been published or submitted for publication elsewhere. Please inform the editorial team if the main findings of your paper have been presented at a conference and published in abstract form, to avoid copyright infringement. |
| رقم الانضمام: | edsbas.B6CD446B |
| قاعدة البيانات: | BASE |
| DOI: | 10.7196/SAMJ.8856 |
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